Imaging-guided stent procedures compared with angiography-guided ones in acute coronary syndrome
Compares imaging-guided and angiography-guided stenting in adults with acute coronary syndrome.
Plain-language title generated from the registry record
Registry title: Optical Coherence Tomography in Acute Vessel Evaluation
Key facts
- Where
- Aalborg, Aarhus N, København Ø, Odense, and Roskilde, DenmarkSee the 5 sites
Where in Denmark
- Aalborg University HospitalAalborg, DenmarkNo longer taking part
- Aarhus University Hospital SkejbyAarhus N, DenmarkNo longer taking part
- RigshospitaletKøbenhavn Ø, DenmarkNo longer taking part
- Odense University HospitalOdense, DenmarkNo longer taking part
- Zealand University Hospital, Roskilde SygehusRoskilde, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus University Hospital Skejby
- Trial code
- NCT07422688
- Record updated
- 9 November 2026
- Original description
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACSRead full original descriptionShow less
Optical Coherence Tomography in Acute Vessel Evaluation (OCTAVE)
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
Inclusion: Clinical inclusion criteria:; NSTEMI, STEMI; Symptom duration <12h for STEMI and <48h for NSTEMI; Age ≥ 18yrs; Ability to provide written informed consent; Angiographic inclusion criteria:; Angiographic signs of at least one possible culprit lesion. Signs including acute occlusion, partial occlusion, proximal embolus, haziness, high grade stenosis, stent thrombosis; Wire in true distal lumen.
Exclusion: Known or anticipated compliance problems with medical therapy; Angiographic exclusion criteria; Known severe heart failure with NYHA class equal or above III; Active bleeding or coagulopathy; Relevant allergies (contrast media, aspirin, clopidogrel, ticagrelor, everolimus); Known ejection fraction <30% before the admission; Known renal failure with GFR <30 ml/min/1.73 m2; Clinical exclusion criteria; Intravascular imaging evaluation of any lesions at index procedure; Cardiogenic shock; Sustained ventricular tachycardia or ventricular fibrillation; Planned CABG; Life expectancy <1 year; Suspected inability to lie flat for the duration of the PCI procedure; Inability to comply with the planned follow-up program; Study lesion involving the Left main coronary artery; Study lesion involving a true bifurcation lesion with a SB >2.5mm; Severe tortuosity; Distal embolus; Isolated coronary artery spasm; Suspected spontaneous coronary artery dissection; Chronic total occlusions with treatment indication and no antegrade intra plaque wire pass.