Genetic testing of breast cancer tumour samples to guide treatment choices
Tests tumour tissue from adults with breast cancer for gene changes using a genomic assay.
Plain-language title generated from the registry record
Registry title: Precision Oncology Clinical Diagnostic Study In Primary and Metastatic Breast Cancer (PRISM)
Key facts
- Where
- Cork, Dublin, and Galway, IrelandSee the 3 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with primary breast cancer having their tumour removed, or with suspected or confirmed breast cancer that has spread to the brain. Their tumour tissue is tested for gene changes.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Primary breast cancer having surgery to remove the tumour, or suspected or confirmed breast cancer that has spread to the brain and is having a biopsy, surgery or treatment.
- Earlier treatment
- People who had treatment before surgery (neoadjuvant treatment) can also join.
Main reasons for not taking part
- No confirmed diagnosis of primary breast cancer
- The study doctor judges that joining is not in the person's best interest
- The study doctor judges the person too frail or in too poor health for the study
- Cannot give informed consent
Read by machine on 13 November 2026.
Where in Ireland
- Cork University HospitalCork, IrelandContact: Cancer Clinical Trials UnitNot yet recruiting
- Beaumont RCSI Cancer CentreDublin, IrelandContact: Cancer Clinical Trials UnitTaking people
- University Hospital GalwayGalway, IrelandContact: Cancer Clinical Trials UnitNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Cancer Trials Ireland
- Trial code
- NCT07425002
- Record updated
- 20 February 2026
- Original description
This study aims to provide information about the genomics of your breast cancer which your oncologist can use to enhance the treatment of your disease possibly enabling more targeted and personalised therapy.This study will carry out TruSight Oncology Comprehensive (TSOComprehensive) testing on breast cancer tumour tissue that was collected at the time of your breast cancer diagnosis or during your breast surgery or if you have brain metastasis and you have had a biopsy for this. The TruSight Oncology Comprehensive assay is a next-generation sequencing (NGS) test used to analyse cancer-related genomic changes in patients, offering a comprehensive view of potential mutations and other alterations that can impact treatment decisions. The TruSight Oncology Comprehensive assay is CE-IVD marked for use in Europe, meaning that it complies with the relevant EU regulation, for comprehensive genomic profiling for different types of cancer. It analyses 523 cancer-relevant genes from both DNA and RNA to identify variations. It will also look for changes and mutations which may affect cell growth and stability. By identifying relevant mutations and biomarkers, the assay can help oncologists select the most appropriate treatment strategies with the aim of improving patient outcomes.Read full original descriptionShow less
Precision Oncology Clinical Diagnostic Study In Primary and Metastatic Breast Cancer (PRISM)
This study aims to provide information about the genomics of your breast cancer which your oncologist can use to enhance the treatment of your disease possibly enabling more targeted and personalised therapy.This study will carry out TruSight Oncology Comprehensive (TSOComprehensive) testing on breast cancer tumour tissue that was collected at the time of your breast cancer diagnosis or during your breast surgery or if you have brain metastasis and you have had a biopsy for this. The TruSight Oncology Comprehensive assay is a next-generation sequencing (NGS) test used to analyse cancer-related genomic changes in patients, offering a comprehensive view of potential mutations and other alterations that can impact treatment decisions. The TruSight Oncology Comprehensive assay is CE-IVD marked for use in Europe, meaning that it complies with the relevant EU regulation, for comprehensive genomic profiling for different types of cancer. It analyses 523 cancer-relevant genes from both DNA and RNA to identify variations. It will also look for changes and mutations which may affect cell growth and stability. By identifying relevant mutations and biomarkers, the assay can help oncologists select the most appropriate treatment strategies with the aim of improving patient outcomes.
Inclusion: Patients diagnosed with primary breast cancer attending hospital for the resection of their tumour tissue. Or Patients with suspected or confirmed brain metastatic breast cancer (Patient has a history of a biopsy or surgically (i.e. pathologically) confirmed primary breast cancer) attending hospital for the resection/biopsy and/or treatment of their tumour tissue. Or Patients with suspected (but not necessarily biopsy confirmed) newly diagnosed brain metastatic breast cancer attending hospital for the resection/biopsy and/or treatment of their tumour tissue; Patients receiving neoadjuvant treatment are also eligible (if applicable); Patients must be ≥ 18 years of age; Patients must be able to give informed consent.
Exclusion: Patients who do not have a confirmed diagnosis of primary breast cancer; Patients whose participation, in the opinion of the PI, would not be in their best interest, or those whom in the opinion of the PI would be unsuitable for study for reasons of infirmity or poor health.