Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
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Contact the study team: see the registry record → Contacts and Locations
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- Who runs it
- Attikon Hospital
- Trial code
- NCT07425457
- Record updated
- 20 February 2026
- Original description
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.Read full original descriptionShow less
Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Inclusion: Adults ≥18 years undergoing primary TKA for osteoarthritis; Cognitively normal and able to self-assess pain and function; Provide written informed consent.
Exclusion: Cancer-related knee pain; Neurological, psychiatric, or medical conditions interfering with assessment; Chronic opioid users.