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Taking people in GreeceNo phase

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Key facts

Where
Athens, GreeceSee the site

Where in Greece

  • Attikon University General HospitalAthens, GreeceContact: Vasileios Balomenos, MD, MSc, PhD(c)Taking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Trial details

Who runs it
Attikon Hospital
Trial code
NCT07425457
Record updated
20 February 2026
Original description
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.Read full original descriptionShow less

Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

Inclusion: Adults ≥18 years undergoing primary TKA for osteoarthritis; Cognitively normal and able to self-assess pain and function; Provide written informed consent.

Exclusion: Cancer-related knee pain; Neurological, psychiatric, or medical conditions interfering with assessment; Chronic opioid users.

ClinicalTrials.gov NCT07425457