Optic Nerve Strain in People Without Glaucoma
Tests latanoprost eye drops and optic nerve photos in people without glaucoma.
Plain-language title generated from the registry record
Registry title: Optic Nerve Head Strain in Non-glaucoma Subjects
Key facts
- Where
- Baltimore, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 90 years old?
Source: NCT07425535, who can take part
Where in United States
- Johns Hopkins HospitalBaltimore, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT07425535
- Record updated
- 13 July 2026
- Original description
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.Read full original descriptionShow less
Optic Nerve Head Strain in Non-glaucoma Subjects
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
Inclusion: Adults who have no history of OAG; Have an ocular examination by a glaucoma specialist with no indications of OAG; Have normal optical coherence tomography findings in the retinal nerve fiber layer; Over age 30 will be included from; Both sexes; All ethnic groups; Optic neuropathy; Both suspects and those with glaucoma damage will be included; When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.
Exclusion: with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret; with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution; inability to understand English or with a language or hearing impairment; in whom sitting in an upright position is impossible due to physical disability; in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable; who cannot perform home tonometry accurately at certification; who do not have reliable clinical Optical Coherence Tomography (OCT) testing; with any form of glaucoma; with high myopia defined as refractive error > -8.