Intensive technology-supported rehabilitation for adults recovering from stroke across care settings
Tests intensive, technology-supported rehabilitation in adults recovering from stroke.
Plain-language title generated from the registry record
Registry title: SwissNeuroRehab - HDHI
Key facts
- Where
- Lausanne, Sullens, Valens, Vitznau, and Zurich, SwitzerlandSee the 5 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07427511, who can take part
Where in Switzerland
- Centre Hospitalier Universitaire VaudoisLausanne, SwitzerlandTaking people
- Swiss Réhabilitation SàrlSullens, SwitzerlandTaking people
- Klinik ValensValens, SwitzerlandTaking people
- Lake Lucerne InstituteVitznau, SwitzerlandNot yet recruiting
- UniversitatSpital ZurichZurich, SwitzerlandNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Universitaire Vaudois
- Trial code
- NCT07427511
- Record updated
- 10 March 2026
- Original description
High-dose, high-intensity (HDHI) neurorehabilitation has shown promise for improving functional outcomes after acquired brain injury (ABI), yet its feasibility and impact across different stages of care and real-world clinical settings remain insufficiently understood.Read full original descriptionShow less
SwissNeuroRehab - High Dose High Intensity Neurorehabilitation Along the Continuum of Care
High-dose, high-intensity (HDHI) neurorehabilitation has shown promise for improving functional outcomes after acquired brain injury (ABI), yet its feasibility and impact across different stages of care and real-world clinical settings remain insufficiently understood.
The SwissNeuroRehab (SNR) initiative, bringing together Swiss rehabilitation centres to develop and evaluate innovative, technology-supported models of neurorehabilitation, provides the broader framework within which this study is conducted.
Within this framework, a structured HDHI therapy pathway supported by CE-marked digital neurorehabilitation tools has been developed for delivery across inpatient, outpatient, and home environments in Switzerland.
This multicentre, non-randomised interventional feasibility study evaluates the feasibility and preliminary clinical effects of implementing this HDHI rehabilitation pathway for adults with stroke in subacute and chronic stages. Participants will receive approximately 300 minutes per week of active, technology-supported training in addition to standard rehabilitation care, following an individually tailored pathway across settings. Standardised clinical assessments, patient-reported outcomes, documentation of rehabilitation procedures, and socioeconomic measures will be collected at baseline, discharge, and follow-up timepoints up to 12-15 months post-enrollment.
The primary aim of the study is to assess the feasibility of the HDHI intervention within routine rehabilitation workflows across multiple Swiss centres. Feasibility will be evaluated through (i) adherence to at least half of the weekly 300-minute Active Training Time target and (ii) patients' perceived feasibility and satisfaction with the program.
Secondary aims are to explore preliminary clinical and functional changes, patient-reported outcomes, and quantify socioeconomic impacts through dedicated surveys and cost data.
Findings from this study will (i) determine whether a structured HDHI rehabilitation pathway can be feasibly implemented across diverse clinical contexts, (ii) provide initial estimates of clinical and socioeconomic outcomes to support planning of future controlled trials.
Inclusion: Adults aged 18-85 years; Confirmed diagnosis of stroke (ischemic or hemorrhagic) >7 days ago; Be able to sit unassisted; Able and willing to give informed consent; Have motor difficulties of the Upper Extremity and/or Lower Extremity; Willing to commit to program length \& daily training dose; Willing to have assessments at start and end of program; Signed informed consent.
Exclusion: Severe cognitive impairment; Uncontrolled seizure disorder or epilepsy - clinician's judgement); Any medical condition that would compromise their safety (inability to communicate, vision or hearing impairment, heart condition that limits participation in exercise) and tolerability (cardiac contraindications); Severe memory disorder; Pain that would limit rehabilitation dose; Severe apraxia; Severe hemispatial neglect; Plegia of the affected limb.