Grouping heart failure patients by clinical data and exercise test responses

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with heart failure with preserved ejection fraction (HFpEF). First, past records are reviewed; a smaller group then does one exercise test visit.

Age

18 years or older

Sex

All sexes can join

Disease stage

Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%).

Main reasons for not taking part

• Incomplete or inadequate medical records (records review phase)
• Medical reason or physical inability that prevents the exercise test (CPET)
• Cannot give informed consent (exercise test phase)

The registry criteria, word for word

What the trial wants to find out

The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).

The group in the trial

• Observational HFpEF Cohort

  Single observational cohort including all adults with an established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%) who received care at the Local Health Unit of the Leiria Region (ULS RL) since September 2018. Clinical, biochemical, imaging, functional, and therapeutic information recorded during previous hospitalizations will be extracted for retrospective analysis. A subset of participants will later be invited to complete a single cardiopulmonary exercise test (CPET) according to the study protocol. Phenotypes (clusters) will be identified post-hoc using unsupervised machine-learning methods and are not predefined at the time of enrollment.