Grouping heart failure patients by clinical data and exercise test responses
Reviews past records of adults with heart failure to find patient subgroups.
Plain-language title generated from the registry record
Registry title: Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Leiria, PortugalSee the 2 sites
Where in Portugal
- ciTechCare - Center for Innovative Care and Health TechnologyLeiria, PortugalNo longer taking part
- Local Health Unit of the Leiria RegionLeiria, PortugalNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Instituto Politécnico de Leiria
- Trial code
- NCT07429396
- Record updated
- 24 February 2026
- Original description
The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).Read full original descriptionShow less
Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction
The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).
The main questions this study aims to answer are:
* Can clinical data be used to identify meaningful HFpEF phenotypes? * Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores? * Do people in different phenotypes show different results on a CPET?
Participants will:
* Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL); * A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise.
This study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.
Inclusion: Retropective observational phase (Phase I):; Age ≥18 years; Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%); Patients receiving care (outpatient or inpatient) at the Local Health Unit of the Leiria Region (ULS RL) since September 2018; Cross-sectional observational phase (Phase II - CPET):; Age ≥18 years; Established diagnosis of HFpEF; Selection as a volunteer representative of phenotypes identified in the retrospective clustering analysis; Provision of written informed consent prior to any study-specific procedures.
Exclusion: Retropective observational phase (Phase I):; Incomplete or inadequate medical records preventing full data extraction; Cross-sectional observational phase (Phase II - CPET):; Medical contraindication or physical inability to perform cardiopulmonary exercise testing (CPET); Inability to provide informed consent.