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Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic

Key facts

Who runs it
Tomas Bata Hospital, Czech Republic
Where
Czechia7 sites in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
400 people, planned
Started
24 Apr 2026
Expected to end
31 Mar 2030
Type of study
Observational
Record updated
9 July 2026

Who can take part

Age
65 years and older
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

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Who can take part

  • Age ≥ 65 years
  • Elective total hip arthroplasty in general or regional anesthesia
  • ASA physical status I-III
  • Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)
  • Expected postoperative hospitalization in ICU, PACU, or standard ward

Who cannot take part

  • Acute reoperation within 3 months of primary surgery
  • Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)
  • Active oncological disease
  • Glasgow Coma Scale ≤ 14
  • Limited legal capacity
  • Chronic use of strong opioids
  • Premedication with anxiolytics or antipsychotics during preanesthetic evaluation
  • Refusal to participate or withdrawal of consent

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.

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The study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.

Approximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.

The group in the trial

  • Cohort of older adults undergoing elective total hip arthroplasty

    Prospective cohort of patients aged 65 years and older undergoing elective total hip arthroplasty in standard clinical care. All participants receive routine perioperative management. No interventions are assigned as part of the study.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Orthopedic Procedures and Postoperative Delirium in the Czech Republic
Record updated
9 July 2026