Neuromodulation to Improve Grasping Function After SCI
Key facts
- Who runs it
- State University of New York at Buffalo
- Where
- Buffalo, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 54 people, planned
- Started
- 1 Apr 2026
- Expected to end
- 30 Jun 2027
- Type of study
- Interventional, 4 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- iTBS
- Sham iTBS
- PCMS
- Sham PCMS
- Exercise
- Record updated
- 23 April 2026
Who can take part
- Age
- 18 years to 75 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- For individuals with SCI:
- Ages 18-75 years
- Chronic SCI (≥1 year of injury)
- Cervical injury at C8 or above
- Individuals who have MEP responses in at least one FDI muscle
Who cannot take part
- Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs
- Uncontrolled medical problems including pulmonary or cardiovascular disease
- History of head injury or stroke
- History of seizures
- Individuals who suffer from a spinal cord disease such as spinal stenosis, spinal bifida or herniated cervical
- Premorbid, ongoing major depression or psychosis, altered cognitive status
- Metal plate in skull
- Pregnant females
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in United States
- The State University of New York at BuffaloBuffalo, United StatesContact: Karen BarnesTaking people
About the trial
What the trial wants to find out
The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.
The 4 groups in the trial
- iTBS and PCMSExisting treatment, for comparison
iTBS and PCMS will be administered and functional and physiological outcomes will be measured before and after the intervention.
Treatment: iTBS and PCMS
- Sham iTBS and PCMSSham treatment, for comparison
Sham iTBS and PCMS will be administered and functional and physiological outcomes will be measured before and after the intervention.
Treatment: Sham iTBS and PCMS
- iTBS and PCMS with exerciseExisting treatment, for comparison
Participants will complete iTBS and PCMS with exercise for 10 sessions.
Treatment: iTBS, PCMS, and Exercise
- Sham iTBS and sham PCMS with exerciseSham treatment, for comparison
Participants will complete sham stimulation with exercise for 10 sessions.
Treatment: Sham iTBS and Sham PCMS
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Neuromodulation to Improve Grasping Function After Spinal Cord Injury
- Fit questions
- Built from NCT07433959, who can take part
- Record updated
- 23 April 2026