Treadmill rehabilitation and gut bacteria in people with Parkinson's disease
Compares treadmill training, with and without virtual reality, on gut bacteria in Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease
Key facts
- Where
- Messina, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07434089, who can take part
Where in Italy
- IRCCS Centro Neurolesi Bonino PulejoMessina, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS Centro Neurolesi Bonino Pulejo
- Trial code
- NCT07434089
- Record updated
- 25 February 2026
- Original description
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.Read full original descriptionShow less
Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.
Inclusion: Diagnosis of PD according to the Movement Disorder Society Clinical; Diagnostic Criteria for Parkinson's Disease; Age comprised between 40 to 70 years; Patients with moderate to advanced disease (2 ≤ Hoehn and Yahr classification grade ≤ 4); Individuals able to walk independently (FAC > 2).
Exclusion: Acute GI phlogosis or GI disease in the last 4 weeks before recruitment; Use of domperidone, or any drug potentially affecting gastrointestinal motility and integrity; Use, in the last 4 weeks preceding the recruitment and until t2, of pre-probiotics or therapy based upon steroids, nonsteroidal anti-inflammatory drugs, antibiotics or antifungals; chronic gastro-intestinal (GI) disease including malabsorption; clinical history of gastric lesions, gastro-resection or major intestinal surgery; systemic and/or neurologic infectious, inflammatory, or autoimmune diseases of gastro-intestinal (GI) eg. Chron disease; anamnesis suggestive of GI cancer pathology; PD patients with (1) weight > 135 kg and Height > 200 cm; Open lesions or bandages whether in contact with the harness of C-Mill strumentation.