Treadmill rehabilitation and gut bacteria in people with Parkinson's disease
Compares treadmill training, with and without virtual reality, on gut bacteria in Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease
Key facts
- Where
- Messina, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 40 to 70 with Parkinson's disease of moderate to advanced severity who can walk on their own. It tests treadmill rehabilitation and its effect on gut bacteria.
- Age
- 40 to 70 years
- Sex
- All sexes can join.
- Disease stage
- Parkinson's disease diagnosed by the Movement Disorder Society criteria, moderate to advanced (Hoehn and Yahr grade 2 to 4).
- Earlier treatment
- No prebiotics or probiotics, steroids, anti-inflammatory painkillers (NSAIDs), antibiotics or antifungals in the last 4 weeks before joining and until the 21-day treatment ends (t2). No domperidone or other drugs that affect gut movement or gut lining.
Main reasons for not taking part
- Weight over 135 kg (298 lb) and height over 200 cm (6 ft 7 in)
- Open wounds or bandages where the C-Mill harness touches
- Long-lasting gut disease, including poor absorption of food
- Stomach lesions, stomach removal or major bowel surgery in the past
- Acute gut inflammation or gut disease in the last 4 weeks, or signs of gut cancer in the history
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07434089, who can take part
Where in Italy
- IRCCS Centro Neurolesi Bonino PulejoMessina, ItalyContact: Maria LuiTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- IRCCS Centro Neurolesi Bonino Pulejo
- Trial code
- NCT07434089
- Record updated
- 25 February 2026
- Original description
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.Read full original descriptionShow less
Gut-Brain Axis and Rehabilitation: Study on the Effects of C-Mill Technology on the Intestinal Microbiota of Parkinson's Disease Patients
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with Parkinson's disease. Three groups will be involved: one undergoing conventional physiotherapy, one treated with the C-Mill without virtual reality (VR), and one treated with C-Mill technology combined with VR. Clinical assessments and the collection of biological samples (stool, serum, and plasma) will be carried out at three time points: at baseline, at the end of treatment (21 days), and after 3 months.
Inclusion: Diagnosis of PD according to the Movement Disorder Society Clinical; Diagnostic Criteria for Parkinson's Disease; Age comprised between 40 to 70 years; Patients with moderate to advanced disease (2 ≤ Hoehn and Yahr classification grade ≤ 4); Individuals able to walk independently (FAC > 2).
Exclusion: Acute GI phlogosis or GI disease in the last 4 weeks before recruitment; Use of domperidone, or any drug potentially affecting gastrointestinal motility and integrity; Use, in the last 4 weeks preceding the recruitment and until t2, of pre-probiotics or therapy based upon steroids, nonsteroidal anti-inflammatory drugs, antibiotics or antifungals; chronic gastro-intestinal (GI) disease including malabsorption; clinical history of gastric lesions, gastro-resection or major intestinal surgery; systemic and/or neurologic infectious, inflammatory, or autoimmune diseases of gastro-intestinal (GI) eg. Chron disease; anamnesis suggestive of GI cancer pathology; PD patients with (1) weight > 135 kg and Height > 200 cm; Open lesions or bandages whether in contact with the harness of C-Mill strumentation.