Screening men over 65 with chest pain for hidden heart amyloidosis
Checks men over 65 with chest pain but no coronary artery disease for cardiac amyloidosis.
Plain-language title generated from the registry record
Registry title: CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
Key facts
- Where
- Copenhagen, DenmarkSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men over 65 who have chest pain but no sign of coronary artery disease on a CT coronary angiogram or Rb-PET scan.
- Age
- 65 years and older
- Sex
- Men only
- Disease stage
- Chest pain with no signs of coronary artery disease on Rb-PET and/or CT coronary angiogram.
Main reasons for not taking part
- Previous history of amyloidosis
Read by machine on 12 November 2026.
Where in Denmark
- RigshospitaletCopenhagen, DenmarkContact: Navid Noory, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07435168
- Record updated
- 27 February 2026
- Original description
The objective of this observational, prospective study is to determine the prevalence of Cardiac Amyloidosis (CA) in males over the age of 65 who experience chest pain but show no signs of coronary artery disease (CAD).Read full original descriptionShow less
CHEST-CA: Study of Chest Pain and Hidden Cardiac Amyloidosis
The objective of this observational, prospective study is to determine the prevalence of Cardiac Amyloidosis (CA) in males over the age of 65 who experience chest pain but show no signs of coronary artery disease (CAD).
Prior to inclusion, all patients will have undergone a CT coronary angiogram or an Rb-PET scan to rule out the possibility of CAD.
Participants will be subject to several examinations, including blood tests, urine samples, ECG, echocardiography, and bone scintigraphy. An endomyocardial biopsy may be conducted if necessary.
Inclusion: No signs of CAD through Rb-PET and/or CT coronary arteriogram.
Exclusion: Previous history of amyloidosis.