Extra Radiation Aimed Inside the Tumor for Large Cervical Cancer
Tests an extra radiation dose to shrink large cervical tumors before internal radiation.
Plain-language title generated from the registry record
Registry title: Intra-lesional Tumor Boost for Bulky Cervical Cancer
Key facts
- Where
- Seongnam-si, South KoreaSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 19 and 80 years old?
Source: NCT07435376, who can take part
Where in South Korea
- Seoul National University Bundang HospitalSeongnam-si, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Seoul National University Bundang Hospital
- Trial code
- NCT07435376
- Record updated
- 27 February 2026
- Original description
The goal of this clinical trial is to learn if adding a radiation boost (intra-lesional boost) works to treat patients with large-sized cervical cancer. It will also learn about the safety of this treatment. The main questions it aims to answer are:Read full original descriptionShow less
A Prospective Phase 2 Clinical Trial of Intra-lesional Cervical Tumor Boost for Bulky Cervical Cancer
The goal of this clinical trial is to learn if adding a radiation boost (intra-lesional boost) works to treat patients with large-sized cervical cancer. It will also learn about the safety of this treatment. The main questions it aims to answer are:
* Does the extra radiation boost effectively reduce the tumor size before the internal radiation (brachytherapy) treatment begins? * What medical problems (side effects) do participants have when receiving this treatment?
Researchers will give this intra-lesional boost to all participants during their standard radiation therapy to see if it helps shrink the tumor more than usual.
Participants will:
* Receive radiation therapy to the pelvis with a targeted boost to the tumor for about 5 to 6 weeks * Visit the clinic daily for radiation treatment and regularly for checkups Have an MRI scan during the 4th or 5th week of treatment to measure the tumor size * Receive internal radiation therapy (brachytherapy) after finishing the external radiation * Visit the clinic for follow-up checkups and tests for up to 2 years
Inclusion: Patients with histologically confirmed squamous cell carcinoma of the cervix; Patients with bulky primary tumor, defined as a tumor volume ≥ 60 cc OR a maximum diameter ≥ 6 cm; Patients aged 19 to 80 years at the time of diagnosis; Patients with an ECOG performance status of 0 to 2; Patients who have voluntarily agreed to participate in the study.
Exclusion: Diagnosis of other malignancies within 5 years prior to enrollment (Exceptions: carcinoma in situ of the breast and thyroid cancer); Patients who are medically unfit for definitive concurrent chemoradiotherapy; Patients who have received prior chemotherapy (neoadjuvant chemotherapy) before radiation therapy; Patients with prior history of radiation therapy to the abdomen or pelvis; Patients unable to provide informed consent due to mental or physical disabilities.