Blood vessel lining and oxidative stress in chronic kidney disease
Studies how the blood vessel lining works in adults with chronic kidney disease.
Plain-language title generated from the registry record
Registry title: Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
Key facts
- Where
- Osijek, CroatiaSee the site
Where in Croatia
- Osijek University HospitalOsijek, CroatiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Josip Juraj Strossmayer University of Osijek
- Trial code
- NCT07437729
- Record updated
- 2 March 2026
- Original description
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).Read full original descriptionShow less
The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in CKD (cross-sectional study 1).
The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CKD, as well as identify new biomarkers for CKD.
Inclusion: patients with CKD of hypertensive etiology (grades 1-2 and 3-5; eGFR CKD-EPI GFR ≥ 90 ml/min/1.73 m², i.e. < 60 mL/min/1.73 m2), non-diabetics, non-smokers; patients with hypertension (according to ESH2023 Guidelines) without kidney damage (eGFR CKD-EPI >90 mL/min/1.73 m2) non-diabetics, non-smokers; healthy volunteer subjects as controls.
Exclusion: kidney disease of any other etiology except hypertension; endocrine, autoimmune or inflammatory diseases that could affect kidney function; diabetes; smoking.