Community PrEP delivery and a phone app to help young people take PrEP
Tests community-based PrEP delivery plus a phone app for young people at risk of HIV.
Plain-language title generated from the registry record
Registry title: Linking Youth to Pre-Exposure Prophylaxis (PrEP) Services
Key facts
- Where
- Atlanta, Baltimore, Houston, and San Francisco, United StatesSee the 4 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 13 and 24 years old?
Source: NCT07438041, who can take part
Where in United States
- Emory Atlanta Adolescent ConsortiumAtlanta, United StatesTaking people
- Johns Hopkins UniversityBaltimore, United StatesTaking people
- Baylor College of MedicineHouston, United StatesTaking people
- San Francisco Department of Public HealthSan Francisco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Westat
- Trial code
- NCT07438041
- Record updated
- 16 October 2026
- Original description
The LYPS intervention is a multi-level intervention that combines: a) structural-level delivery of PrEP and PrEP services by a community health professional (CHP) at a designated place in the community being offered by the SC where PrEP is not yet provided (e.g., participant's home, community partner location, or traveling mobile van), with b) an individual-level mobile application (app) to support PrEP adherence and persistence between CHP visits.Read full original descriptionShow less
Linking Youth to Pre-Exposure Prophylaxis (PrEP) Services (LYPS): An Innovative Mobile Delivery and Mobile Health (mHealth) Intervention to Optimize PrEP Adherence and Persistence
The LYPS intervention is a multi-level intervention that combines: a) structural-level delivery of PrEP and PrEP services by a community health professional (CHP) at a designated place in the community being offered by the SC where PrEP is not yet provided (e.g., participant's home, community partner location, or traveling mobile van), with b) an individual-level mobile application (app) to support PrEP adherence and persistence between CHP visits.
Inclusion: Age 13-24 years, inclusive; Reports anal or vaginal sex in the past year; Is not living with HIV; Weighs at least 35 kilograms (77 pounds); Willing to receive PrEP care from a provider at a participating SC either in the clinic or at one of the designated places in the community being offered by the SC SC; Has an Android-based smartphone or iPhone; Has fluency in English (able to read, speak, and understand English); and; Willing to provide informed consent to participate in the study.
Exclusion: Concurrent participation in ATN 166, ATN 170, or any other clinical trial providing HIV medications (PrEP, vaccine, etc.) or currently receiving any PrEP-adherence or persistence behavioral intervention; or; Has any clinically significant systemic disease (including but not limited to significant or uncontrolled liver disease, gastrointestinal disease, kidney disease, thyroid disease, osteoporosis, or bone disease) or diabetes; Any other medical, behavioral, or other conditions that, in the opinion of the SC project lead or designee, could interfere with adherence to study procedures or compromise interpretation of study results; Has counter-indications for PrEP according to guidelines and approved local label; Is currently incarcerated or pending incarceration.