Software that measures the aorta on CT scans, compared with radiologists
Tests Aorta AIM software measuring aortic size on existing CT scans of adults.
Key facts
- Who runs it
- Aiatella Oy
- Where
- Chapel Hill and Norfolk, United StatesSee the 2 sitesAlso in 1 other country, 1 site
- Trial code
- Registry title
- AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation
- Status
- Recruiting
- People taking part
- 250 people, planned
- Started
- 31 Mar 2026
- Planned end
- 5 Sept 2026
- Type of study
- Observational
- Treatments tested
- Aorta AIM Automated Measurement
- Expert Radiologist Manual Measurement
- Record updated
- 6 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who already had a CT scan of the chest or belly that shows the aorta, the body's main blood vessel. Only existing scans are used to test an AI measuring tool.
- Age
- 22 years and older at the time of the scan
- Sex
- All sexes
- Disease stage
- CT scan of the whole, chest or belly part of the aorta, taken from 1 Jan 2016 to 31 August 2025. Scan slices must be ≤ 3mm thick. Scans with or without contrast dye can be used.
- Earlier treatment
- People who had surgery on the aorta before cannot join.
Main reasons for not taking part
- Scan cut off so a part of the aorta cannot be measured reliably (only that part is left out)
- Metal implants <5cm (2 in) from the aorta, such as a chest stent
- Earlier aortic surgery or repair of the aorta after an injury
- Strong blurring from movement on the scan (>3mm)
- Aorta problems present from birth, or having opted out of research use of your data
The registry criteria, word for word
Show all 11 criteriaShow less
Other criteria
- Adults ≥22 years at time of imaging
- Studies performed 1 Jan 2016 - 31 August 2025
- CT imaging of the whole, thoracic, or abdominal aorta, with or without contrast enhancement, acquired with any gating protocol (including non-gated)
- Slice thickness ≤ 3mm
- CT imaging in which truncation creates discontinuity within a targeted aortic region, preventing reliable diameter measurement (e.g., cardiac-focused CT acquisitions where an incomplete or absent aortic arch creates discontinuity between the aortic root and the descending thoracic aorta); o Partial aortic coverage is not grounds for exclusion. Where truncation affects individual regions, only those specific regions will be excluded from analysis; remaining fully captured regions will be retained for measurement
- Metal implants <5cm from aorta (e.g. thoracic stent)
- Prior aortic surgery
- Severe motion artifacts (e.g. >3mm vessel blurring)
- Congenital aortic anomalies (e.g. coarctation, vascular rings)
- Post-traumatic aortic repairs
- The patient opted out of having their data used for medical research before the date of cross-referencing by the site team
Where in United States
Also in 1 other country, 1 site
- University of North Carolina at Chapel HillChapel Hill, United StatesContact: Dr. Behrooz MasuodiNot yet recruiting
- Innovation Health ServicesNorfolk, United StatesContact: Dr. Huma Samar, MDTaking people
About the trial
What the trial wants to find out
This study will test how well an artificial intelligence (AI) software called Aorta AIM measures the size of the aorta (the body's main blood vessel) from CT scans. The aorta can become enlarged over time, which may lead to serious health problems. Doctors need to measure the aorta accurately to monitor patients and decide on treatment.
Read full original descriptionShow less
Currently, doctors measure the aorta manually on CT scans, which takes time and can vary between different doctors. Aorta AIM is designed to measure the aorta automatically and consistently.
In this study, researchers will compare Aorta AIM's measurements to those made by experienced radiologists or cardiologists (doctors who specialize in reading medical images). The study will use CT scans that have already been taken as part of routine medical care - no additional scans or procedures are needed.
The study will include approximately 250 participants across multiple hospitals in Brazil and the United States. Participants will be adults who have had a chest or abdominal CT scan that shows their aorta.
The main goals are to:
* Check if Aorta AIM measures the aorta as accurately as radiologists * See if Aorta AIM can help doctors work more efficiently * Evaluate if the software works well in different hospital settings and with different types of patients
This research may help improve how doctors monitor aortic disease and make treatment decisions in the future. There are no risks to participants since the study only uses existing medical images.
The group in the trial
- Validation Cohort
Adults who have undergone chest or abdominal CT imaging (with or without contrast) as part of routine clinical care. CT scans will be retrospectively collected and processed by both Aorta AIM software and expert radiologists to validate automated aortic diameter measurements.
Treatment: Aorta AIM Automated Measurement and Expert Radiologist Manual Measurement
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation - Clinical Evaluation of Aorta Automated Imaging Measurement (Aorta AIM)
- Plain-language title
- Software that measures the aorta on CT scans, compared with radiologistsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 6 April 2026