How cycling exercise affects the brain in Parkinson's disease with deep brain stimulation
Studies how forced and voluntary cycling affect movement, thinking and brain activity in Parkinson's.
Plain-language title generated from the registry record
Registry title: Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
Key facts
- Where
- Cleveland, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Cleveland ClinicCleveland, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Cleveland Clinic
- Trial code
- NCT07442747
- Record updated
- 26 October 2026
- Original description
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.Read full original descriptionShow less
Neural Mechanisms Underlying the Benefits of Aerobic Exercise in Advanced Parkinson's Disease
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.
Inclusion: Clinical diagnosis of Parkinson's disease; Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD; Clinically optimized DBS parameters for one month prior to enrollment; Ability to ambulate with or without an assistive device for 5 continuous minutes; Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments; Medical clearance for moderate-high intensity exercise given by treating physician or physician extender.
Exclusion: Neurocognitive impairment that compromises the ability to provide informed consent; Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke); Current cardiac arrhythmia; A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise.