Aerobic Exercise and Fatigue in People With Friedreich's Ataxia
Tests home aerobic exercise in people with Friedreich's ataxia, with or without omaveloxolone.
Plain-language title generated from the registry record
Registry title: Cardiac Output and Fatigue in Friedreich's Ataxia
Key facts
- Where
- New York, United StatesSee the site
Where in United States
- Columbia University Irving Medical CenterNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Scott Barbuto
- Trial code
- NCT07444333
- Record updated
- 22 September 2026
- Original description
This is a clinical trial examining to impact of aerobic training plus omaveloxolone in FRDA. Thirty individuals with FRDA will be recruited; 20 individuals will be on omaveloxolone treatment whereas the other ten individuals will not. Individuals will undergo baseline assessment including cardiopulmonary exercise testing (CPET), mFARS, gait speed, Timed Up and Go (TUG), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), and 6-minute Walk Test (6MWT). Individuals will then perform 3-months of home aerobic training. Repeat assessments will be conducted at 3- and 6-months.Read full original descriptionShow less
Cardiac Output and Fatigue in Friedreich's Ataxia
This is a clinical trial examining to impact of aerobic training plus omaveloxolone in FRDA. Thirty individuals with FRDA will be recruited; 20 individuals will be on omaveloxolone treatment whereas the other ten individuals will not. Individuals will undergo baseline assessment including cardiopulmonary exercise testing (CPET), mFARS, gait speed, Timed Up and Go (TUG), Fatigue Severity Scale (FSS), Fatigue Impact Scale (FIS), and 6-minute Walk Test (6MWT). Individuals will then perform 3-months of home aerobic training. Repeat assessments will be conducted at 3- and 6-months.
Inclusion: Genetically confirmed FRDA; Ability to safely ride a stationary bicycle (mFARS sitting posture sub-score <2).
Exclusion: Disorders that interfere with ability to perform endurance exercise (e.g., stroke, respiratory problems, traumatic brain injury, or neuromuscular disease); Evidence of serious arrhythmias or ischemic heart disease; Beck depression score >19, a score that precludes ability to exercise; Montreal Cognitive Assessment (MoCA) score <23/30; Regular participation in vigorous endurance exercise (defined as >2 days/week for at least the past 4 months at max HR>65%).