Two types of magnetic brain stimulation for thinking problems in treatment-resistant schizophrenia
Compares two magnetic brain stimulation types with sham for cognition in schizophrenia.
Plain-language title generated from the registry record
Registry title: Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia
Key facts
- Where
- Bhubaneswar, IndiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT07445620, who can take part
Where in India
- AIIMS, BhubaneswarBhubaneswar, IndiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- All India Institute of Medical Sciences, Bhubaneswar
- Trial code
- NCT07445620
- Record updated
- 10 August 2026
- Original description
This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.Read full original descriptionShow less
Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia: DB-RCT
This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.
Inclusion: Diagnosed with treatment-resistant schizophrenia according to TRIIP Consensus criteria; Age: 18-60 years; Currently receiving clozapine treatment for at least 6 months; Attending psychiatry outpatient department at AIIMS Bhubaneswar.
Exclusion: Currently receiving or recently received ECT/rTMS/tDCS; Co-morbid psychiatric, major medical, or neurological disorders; History of withdrawal seizures, delirium tremens, or significant head injury; Presence of pacemaker or metal in any part of body (excluding mouth); Pregnant or lactating women.