Brain network changes in essential tremor after focused ultrasound treatment

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with essential tremor who are having High-Intensity Focused Ultrasound (HiFU) treatment. It studies how brain networks change after the treatment.

Age

Older than 50 years and younger than 85 years.

Sex

All sexes can join.

Disease stage

Essential tremor that has not improved enough with tremor medicines.

Earlier treatment

Tremor did not respond to at least 2 first line tremor medications.

Biomarker or test result

Skull Density Ratio (SDR) of 0.35 or more, measured from skull scans.

Main reasons for not taking part

• Implants or devices that cannot go in MR or MEG scanners, such as a pacemaker
• Head tremor that disturbs the MEG brain recording
• Severe depression and/or anxiety
• Severe problems with memory and thinking

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 50 and 84 years old?YesNo

What the trial wants to find out

The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU). Essential tremor is a movement disorder that causes shaking, usually in the hands, and can make everyday tasks difficult. HiFU is a treatment that uses focused sound waves to target a small area in the brain involved in tremor. In this study, the investigators aim to understand how this treatment affects the brain's networks by using safe, non-invasive tests such as brain imaging, brain wave recordings, and movement assessments.

The group in the trial

• Essential Tremor refractory to at least 2 first line tremor medicationsTreatment being tested

  Eligible patients will have MRI and fMRI scans, MEG recordings, sensor-based motor assessments, clinical evaluations and questionnaires and rating scales before the treatment, right after, and again at 6 weeks and 6 months afterward.

  Treatment: MRI and fMRI scans, MEG, Sensor-based motor assessments, Clinical evaluations, and Questionnaires and rating scales that