Vision and hearing tests in people at risk of or with early psychosis
Compares sensory tests in young adults at risk of or with early psychosis.
Plain-language title generated from the registry record
Registry title: Perception and Integration of Sensory Information in the Early Stages of Psychosis
Key facts
- Where
- Bron, Laxou, Saint-Égrève, and Saint-Priest-en-Jarez, FranceSee the 4 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 30 years old?
Source: NCT07446569, who can take part
Where in France
- Centre Hospitalier Le VinatierBron, FranceNo longer taking part
- Centre Psychothérapique de NancyLaxou, FranceNo longer taking part
- Centre Hospitalier Alpes-IsèreSaint-Égrève, FranceNo longer taking part
- Centre Hospitalier Universitaire de Saint EtienneSaint-Priest-en-Jarez, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Psychothérapique de Nancy
- Trial code
- NCT07446569
- Record updated
- 3 March 2026
- Original description
The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:Read full original descriptionShow less
Perception and Integration of Sensory Information in the Early Stages of Psychosis
The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:
* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk? * How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?
Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.
Participants will:
* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task. * Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials). * Provide demographic, clinical, and neuropsychological data during study visits. * For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.
Inclusion: All groups:; Age between 18 and 30 years; Normal or corrected-to-normal visual acuity; Affiliated with or dependent on a social security health insurance plan; Provided informed consent and co-signed the study consent form with the investigator; Proficient in French; Control group (TEM) specific criteria:; No current psychiatric disorder (DSM-IV Axis I), except anxiety disorders; No lifetime history of (hypo)manic episodes or psychotic disorders; No first-degree family history of schizophrenia spectrum disorders; No regular use (more than one month continuously) in the past 6 months of the following medications: benzodiazepines, hypnotics, antidepressants, antipsychotics, mood stabilizers, or psychostimulants; Clinical High-Risk (CHR) group specific criteria:; -Meet CHR criteria according to CAARMS: Attenuated positive symptoms (APS) below clinical threshold in intensity or frequency OR Brief Limited Intermittent Psychotic Symptoms (SPLI) OR Genetic Risk; First-Episode Psychosis (PEP) group specific criteria:; -Meet PEP criteria according to CAARMS (psychosis threshold reached).
Exclusion: Impairment that makes participation in the study or understanding of information difficult or impossible; Current substance use disorder (DAST score >6); Cannabis use disorder (CUDIT-R score ≥13); History of neurological disorders, including progressive neurological disease; Progressive retinal disease; Ophthalmologic conditions affecting visual acuity; Current eye infection; Hearing disorders affecting auditory acuity; Criteria incompatible with the electroretinographic device:; Presence of photosensitive epilepsy; Allergy to components of the electrode gel; Pregnant, postpartum, or breastfeeding women; Individuals deprived of liberty by judicial or administrative decision; Individuals in a life-threatening emergency; Adults under legal protection measures; Adults unable to provide consent and not under legal protection; Alcohol dependence (AUDIT score ≥12 for men, ≥11 for women); Chronic glaucoma; Behavioral problems causing extreme agitation or aggression; Eye or surrounding tissue lesions that may come into contact with the device.