Exercise With or Without Brain Training for Walking in Older Veterans With Multiple Sclerosis
Compares exercise alone with exercise plus brain training in older veterans with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Exercise With and Without Cognitive Training
Key facts
- Where
- Decatur, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 55 and 85 years old?
Source: NCT07447115, who can take part
Where in United States
- Atlanta VA Medical and Rehab Center, Decatur, GADecatur, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT07447115
- Record updated
- 3 March 2026
- Original description
This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.Read full original descriptionShow less
The Effect of Exercise With and Without Cognitive Training on Gait in Older Veterans With Multiple Sclerosis
This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.
Inclusion: US Veteran; Diagnosis of Multiple Sclerosis; Relapse free in the last 30 days; Capable of standing unaided for at least 1 minute; Expanded Disability Status Scale <6.5; Ability to speak and understand English.
Exclusion: Any neurological disorder other than MS; Modified Telephone Interview for Cognitive Status <20; Current participation in an exercise or cognitive rehabilitation study.