Freezing treatment for early luminal breast cancer in postmenopausal women
Tests freezing tumors with liquid nitrogen in postmenopausal women with early luminal breast cancer.
Plain-language title generated from the registry record
Registry title: Luminal Breast Cancer Cryoablation
Key facts
- Where
- Lugo, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for postmenopausal women with a small, single, early breast cancer that is hormone receptor positive and HER2 negative. It tests freezing the tumour with liquid nitrogen (cryoablation).
- Sex
- Women only
- Disease stage
- Invasive breast cancer in one spot only (unifocal), 2 cm (0.8 in) or smaller, with no lymph node involvement in the armpit on ultrasound. Luminal type: estrogen and/or progesterone receptor positive.
- Biomarker or test result
- Estrogen and/or progesterone receptor positive; HER2 negative.
Main reasons for not taking part
- Infiltrating lobular carcinoma
- Large in situ (non-invasive) component
- Tumour in more than one spot (multifocal or multicentric)
- Cannot have contrast mammography
- Not a candidate for surgery or has distant metastasis
Read by machine on 9 November 2026.
Where in Spain
- Hospital Universitario Lucus AugustiLugo, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Lucía Graña López
- Trial code
- NCT07447414
- Record updated
- 16 April 2026
- Original description
LUBRECA will evaluate the safety and efficacy of cryoablation with liquid nitrogen to treat cT1cN0 luminal breast cancer diagnosed in postmenopausal womenRead full original descriptionShow less
Cryoablation for the Treatment of Luminal Early Breast Cancer
LUBRECA will evaluate the safety and efficacy of cryoablation with liquid nitrogen to treat cT1cN0 luminal breast cancer diagnosed in postmenopausal women
Inclusion: Postmenopausal women diagnosed with invasive breast cancer by core needle biopsy or vacuum-assisted biopsy; Unifocal; Lesion ≤ 2 cm (on ultrasound and contrast enhanced mammography); No axillary lymphadenopathy on ultrasound; No axillary lymph node involvement on ultrasound; Luminal tumor (estrogen and/or progesterone receptor positive); HER2 negative; Signed informed consent.
Exclusion: Not candidate for surgery; Infiltrating lobular carcinoma; Extensive in situ component; Multifocality or multicentricity; Contraindication for contrast mammography; Distant metastasis -.