SIRI Levels Following PENG Block in Hip Arthroplasty
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Trial details
- Who runs it
- Poznan University of Medical Sciences
- Trial code
- NCT07449403
- Record updated
- 6 November 2026
- Original description
This randomized controlled trial evaluates the effect of ultrasound-guided Pericapsular Nerve Group (PENG) block on the Systemic Inflammation Response Index (SIRI) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SIRI, calculated as neutrophil count × monocyte count / lymphocyte count, is used as a composite marker of perioperative inflammatory response. The study investigates whether PENG block attenuates the systemic inflammatory reaction to surgical trauma compared to sham block. The study investigates whether PENG block attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.Read full original descriptionShow less
Pericapsular Nerve Group Block Mitigates Surgical Stress and Enhances Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial
This randomized controlled trial evaluates the effect of ultrasound-guided Pericapsular Nerve Group (PENG) block on the Systemic Inflammation Response Index (SIRI) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SIRI, calculated as neutrophil count × monocyte count / lymphocyte count, is used as a composite marker of perioperative inflammatory response. The study investigates whether PENG block attenuates the systemic inflammatory reaction to surgical trauma compared to sham block. The study investigates whether PENG block attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.
Inclusion: Patients with ASA classification I-III; Aged 65-100 years; Who will be scheduled for hip arthroplasty under spinal anesthesia.
Exclusion: Take anticoagulant therapy; Patients who have a history of bleeding diathesis; History of chronic pain before surgery; patients unable to assess their pain (dementia); patients having an infection in the region of the procedure; Multiple trauma; patients operated under general anesthesia; the patient who does not accept the procedure.