Periodontal Status and TMAO Levels in Peripheral Artery Disease
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Trial details
- Who runs it
- Ankara University
- Trial code
- NCT07449546
- Record updated
- 4 November 2026
- Original description
This observational study aims to evaluate the association between periodontal status and trimethylamine-N-oxide (TMAO) levels in patients diagnosed with peripheral artery disease (PAD). Both serum and saliva TMAO concentrations will be measured and compared according to periodontal health, periodontitis, and edentulism status. Clinical periodontal examinations and biological sample collection will be performed. The study seeks to investigate whether oral health status is associated with systemic TMAO levels in individuals with PAD.Read full original descriptionShow less
Evaluation of the Effect of Periodontal Status on Serum and Salivary Trimethylamine N-Oxide Levels in Individuals With Peripheral Artery Disease
This observational study aims to evaluate the association between periodontal status and trimethylamine-N-oxide (TMAO) levels in patients diagnosed with peripheral artery disease (PAD). Both serum and saliva TMAO concentrations will be measured and compared according to periodontal health, periodontitis, and edentulism status. Clinical periodontal examinations and biological sample collection will be performed. The study seeks to investigate whether oral health status is associated with systemic TMAO levels in individuals with PAD.
Inclusion: Adults aged ≥18 years; Confirmed diagnosis of Peripheral Arterial Disease (PAD), defined as: Ankle-Brachial Index (ABI) < 0.9 and/or angiographic or ultrasonographic evidence of arterial stenosis; No limb amputation; Presence of teeth and willingness to undergo full-mouth periodontal examination; Edentulous status with self-reported history of complete tooth loss due to advanced periodontitis; Ability to provide informed consent.
Exclusion: Systemic antibiotic use within the previous 3 months; Corticosteroid use within the previous 3 months; Immunosuppressive therapy within the previous 3 months; Chronic non-steroidal anti-inflammatory drug (NSAID) use within the previous 3 months; Active periodontal treatment within the previous 6 months; Periodontal surgery within the previous 1 year; Pregnant individuals; Use of oral contraceptives.