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NCT07449923Active, not recruitingPhase 3

CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
240 (estimated)
First submitted
27 Feb 2026
Start date
9 Feb 2026
Primary completion date
Oct 2027
Lead sponsor
EyePoint Pharmaceuticals, Inc.
NCT number
NCT07449923

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 240
  • From 9 Feb 2026 to the primary completion date, Oct 2027
  • 70 sites in 5 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • BCVA using ETDRS charts \<30 letters (20/250 Snellen equivalent) in the fellow eye.

Who the study is looking for

  • Previously treated or treatment naïve patients with a documented diagnosis of macular edema associated with diabetic retinopathy (DR) in the study eye, with onset of disease that began at any time prior to the Screening Visit.
  • Best-corrected visual acuity (BCVA) Early Treatment Diabetic Retinopathy Study (ETDRS) letter score of 35 letters (20/200 Snellen equivalent) to 78 letters (20/32 Snellen equivalent) in the study eye at the Screening Visit and at Baseline (Day 1).
  • For previously treated participants: at least 1 injection of anti-VEGF in the past 12 months, the most recent anti-VEGF treatment for DME must not have been administered less than 12 weeks prior to the Screening Visit.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (70)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Retina Prime at Jardim Europa Medical Center
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AracajuBrazilUnknown status
Centro Brasileiro de Pesquisa Clinica - Blumenau
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BlumenauBrazilUnknown status
Retina Clinic-Jardim America
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São PauloBrazilUnknown status
IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia
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São PauloBrazilUnknown status
UNIFESP - Hospital Sao Paulo
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São PauloBrazilUnknown status
VISUS, spol s.r.o.
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NáchodCzechiaUnknown status
Fakultni nemocnice Kralovske Vinohrady
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PragueCzechiaUnknown status
Vseobecna fakultni nemocnice v Praze
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PragueCzechiaUnknown status
Axon Clinical s.r.o.
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PragueCzechiaUnknown status
Medical Private Care s.r.o.
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SokolovCzechiaUnknown status
St. Elisabeth Krankenhaus
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CologneGermanyUnknown status
Bajcsy-Zsilinszky Korhaz es Rendelointezet
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BudapestHungaryUnknown status
Semmelweis Egyetem
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BudapestHungaryUnknown status
Budapest Retina Associates
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BudapestHungaryUnknown status
EPC-Honvedkorhaz
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BudapestHungaryUnknown status
Debreceni Egyetem KK Szemklinika
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DebrecenHungaryUnknown status
PTE KK Ophthalmology Clinic (Optimum Szemeszet)
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PécsHungaryUnknown status
Ganglion Medical Center
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PécsHungaryUnknown status
SzTE KK Szemeszeti Klinika
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SzegedHungaryUnknown status
Vision Research Center at Eye Associates of New Mexico
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AlbuquerqueUnited StatesUnknown status
Retina Specialists of Colorado - Arvada
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ArvadaUnited StatesUnknown status
Austin Clinical Research, LLC
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AustinUnited StatesUnknown status
Retina Consultants of Texas
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BellaireUnited StatesUnknown status
Retina and Vitreous of Texas
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BellaireUnited StatesUnknown status
Retina-Vitreous Associates Medical Group
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Beverly HillsUnited StatesUnknown status
Retina Center of New Jersey
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BloomfieldUnited StatesUnknown status
Associated Vitreoretinal & Uveitis Consultants - Carmel
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CarmelUnited StatesUnknown status
Connecticut Eye Consultants, P.C.
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DanburyUnited StatesUnknown status
Retina Vitreous Center, PLLC
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EdmondUnited StatesUnknown status
Retina Associates
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ElmhurstUnited StatesUnknown status
Verum Research, LLC
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EugeneUnited StatesUnknown status
The Retina Group of Washington
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FairfaxUnited StatesUnknown status
Carolinas Centers for Sight, P.C. - Florence Campus
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FlorenceUnited StatesUnknown status
Retina Group of Florida - Fort Lauderdale
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Fort LauderdaleUnited StatesUnknown status
Retina Consultants of Orange County
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FullertonUnited StatesUnknown status
Charles Retina Institute
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GermantownUnited StatesUnknown status
Associated Retina Consultans
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GilbertUnited StatesUnknown status
Coastal Eye Surgeons, LLC
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GreenwichUnited StatesUnknown status
Cumberland Valley Retina Consultants
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HagerstownUnited StatesUnknown status
Mid Atlantic Retina Specialists - Hagerstown
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HagerstownUnited StatesUnknown status
Graystone Eye - Hickory Office
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HickoryUnited StatesUnknown status
University Retina and Macula Associates
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LemontUnited StatesUnknown status
Retina Vitreous Surgeons of CNY, PC
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LiverpoolUnited StatesUnknown status
South Coast Retina Center
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Long BeachUnited StatesUnknown status
The Eye Care Institute
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LouisvilleUnited StatesUnknown status
Retina Associates New Orleans
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MetairieUnited StatesUnknown status
Retinal Consultants Medical Group - Modesto
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ModestoUnited StatesUnknown status
Kaiser Permanente
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OaklandUnited StatesUnknown status
Illinois Retina Associates, S.C.
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Oak ParkUnited StatesUnknown status
Retina Specialty Institute
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PensacolaUnited StatesUnknown status
Wills Eye Hospital
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PhiladelphiaUnited StatesUnknown status
Phoenix Retina Clinical Trials, LLC - North Phoenix
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PhoenixUnited StatesUnknown status
Associated Retina Consultants - Phoenix
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PhoenixUnited StatesUnknown status
Fort Lauderdale Eye Institute
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PlantationUnited StatesUnknown status
Retina Consultants of Southern California
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RedlandsUnited StatesUnknown status
Retina Associates of South Texas
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San AntonioUnited StatesUnknown status
San Antonio Eye Center
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San AntonioUnited StatesUnknown status
Retina Macula Institute of Arizona
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ScottsdaleUnited StatesUnknown status
MedEye Associates
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South MiamiUnited StatesUnknown status
The Retina Institute
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St LouisUnited StatesUnknown status
Retina Vitreous Associates of Florida - Saint Petersburg
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St. PetersburgUnited StatesUnknown status
Retina Vitreous Associates of Florida
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TampaUnited StatesUnknown status
Retina Consultants of Texas
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The WoodlandsUnited StatesUnknown status
Tyler Retina Consultants
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TylerUnited StatesUnknown status
North Carolina Retina Associates
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Wake ForestUnited StatesUnknown status
Bay Area Retina Associates
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Walnut CreekUnited StatesUnknown status
Retina Group of New England, PC
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WaterfordUnited StatesUnknown status
Eye Clinic of Wisconsin
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WausauUnited StatesUnknown status
Strategic Clinical Research Group, LLC
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Willow ParkUnited StatesUnknown status
Vitreo-Retinal Associates, PC
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WorcesterUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.