NCT07449923Active, not recruitingPhase 3
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- First submitted
- 27 Feb 2026
- Start date
- 9 Feb 2026
- Primary completion date
- Oct 2027
- Lead sponsor
- EyePoint Pharmaceuticals, Inc.
- Diseases
- Diabetic eye disease
- NCT number
- NCT07449923
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 240
- From 9 Feb 2026 to the primary completion date, Oct 2027
- 70 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- BCVA using ETDRS charts \<30 letters (20/250 Snellen equivalent) in the fellow eye.
Who the study is looking for
- Previously treated or treatment naïve patients with a documented diagnosis of macular edema associated with diabetic retinopathy (DR) in the study eye, with onset of disease that began at any time prior to the Screening Visit.
- Best-corrected visual acuity (BCVA) Early Treatment Diabetic Retinopathy Study (ETDRS) letter score of 35 letters (20/200 Snellen equivalent) to 78 letters (20/32 Snellen equivalent) in the study eye at the Screening Visit and at Baseline (Day 1).
- For previously treated participants: at least 1 injection of anti-VEGF in the past 12 months, the most recent anti-VEGF treatment for DME must not have been administered less than 12 weeks prior to the Screening Visit.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (70)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Retina Prime at Jardim Europa Medical Center Coordinator of this site? Confirm its status | Aracaju | Brazil | Unknown status |
| Centro Brasileiro de Pesquisa Clinica - Blumenau Coordinator of this site? Confirm its status | Blumenau | Brazil | Unknown status |
| Retina Clinic-Jardim America Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| UNIFESP - Hospital Sao Paulo Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| VISUS, spol s.r.o. Coordinator of this site? Confirm its status | Náchod | Czechia | Unknown status |
| Fakultni nemocnice Kralovske Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Vseobecna fakultni nemocnice v Praze Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Axon Clinical s.r.o. Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Medical Private Care s.r.o. Coordinator of this site? Confirm its status | Sokolov | Czechia | Unknown status |
| St. Elisabeth Krankenhaus Coordinator of this site? Confirm its status | Cologne | Germany | Unknown status |
| Bajcsy-Zsilinszky Korhaz es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| Semmelweis Egyetem Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| Budapest Retina Associates Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| EPC-Honvedkorhaz Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| Debreceni Egyetem KK Szemklinika Coordinator of this site? Confirm its status | Debrecen | Hungary | Unknown status |
| PTE KK Ophthalmology Clinic (Optimum Szemeszet) Coordinator of this site? Confirm its status | Pécs | Hungary | Unknown status |
| Ganglion Medical Center Coordinator of this site? Confirm its status | Pécs | Hungary | Unknown status |
| SzTE KK Szemeszeti Klinika Coordinator of this site? Confirm its status | Szeged | Hungary | Unknown status |
| Vision Research Center at Eye Associates of New Mexico Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Retina Specialists of Colorado - Arvada Coordinator of this site? Confirm its status | Arvada | United States | Unknown status |
| Austin Clinical Research, LLC Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Retina and Vitreous of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Retina-Vitreous Associates Medical Group Coordinator of this site? Confirm its status | Beverly Hills | United States | Unknown status |
| Retina Center of New Jersey Coordinator of this site? Confirm its status | Bloomfield | United States | Unknown status |
| Associated Vitreoretinal & Uveitis Consultants - Carmel Coordinator of this site? Confirm its status | Carmel | United States | Unknown status |
| Connecticut Eye Consultants, P.C. Coordinator of this site? Confirm its status | Danbury | United States | Unknown status |
| Retina Vitreous Center, PLLC Coordinator of this site? Confirm its status | Edmond | United States | Unknown status |
| Retina Associates Coordinator of this site? Confirm its status | Elmhurst | United States | Unknown status |
| Verum Research, LLC Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| The Retina Group of Washington Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Carolinas Centers for Sight, P.C. - Florence Campus Coordinator of this site? Confirm its status | Florence | United States | Unknown status |
| Retina Group of Florida - Fort Lauderdale Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Retina Consultants of Orange County Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Charles Retina Institute Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Associated Retina Consultans Coordinator of this site? Confirm its status | Gilbert | United States | Unknown status |
| Coastal Eye Surgeons, LLC Coordinator of this site? Confirm its status | Greenwich | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Mid Atlantic Retina Specialists - Hagerstown Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Graystone Eye - Hickory Office Coordinator of this site? Confirm its status | Hickory | United States | Unknown status |
| University Retina and Macula Associates Coordinator of this site? Confirm its status | Lemont | United States | Unknown status |
| Retina Vitreous Surgeons of CNY, PC Coordinator of this site? Confirm its status | Liverpool | United States | Unknown status |
| South Coast Retina Center Coordinator of this site? Confirm its status | Long Beach | United States | Unknown status |
| The Eye Care Institute Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Retina Associates New Orleans Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Retinal Consultants Medical Group - Modesto Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Kaiser Permanente Coordinator of this site? Confirm its status | Oakland | United States | Unknown status |
| Illinois Retina Associates, S.C. Coordinator of this site? Confirm its status | Oak Park | United States | Unknown status |
| Retina Specialty Institute Coordinator of this site? Confirm its status | Pensacola | United States | Unknown status |
| Wills Eye Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Phoenix Retina Clinical Trials, LLC - North Phoenix Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Associated Retina Consultants - Phoenix Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Fort Lauderdale Eye Institute Coordinator of this site? Confirm its status | Plantation | United States | Unknown status |
| Retina Consultants of Southern California Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Retina Associates of South Texas Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| San Antonio Eye Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Macula Institute of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
| MedEye Associates Coordinator of this site? Confirm its status | South Miami | United States | Unknown status |
| The Retina Institute Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Retina Vitreous Associates of Florida - Saint Petersburg Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Retina Consultants of Texas Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Tyler Retina Consultants Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Wake Forest | United States | Unknown status |
| Bay Area Retina Associates Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Retina Group of New England, PC Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| Eye Clinic of Wisconsin Coordinator of this site? Confirm its status | Wausau | United States | Unknown status |
| Strategic Clinical Research Group, LLC Coordinator of this site? Confirm its status | Willow Park | United States | Unknown status |
| Vitreo-Retinal Associates, PC Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.