Right heart strain during artificial ventilation in acute respiratory distress syndrome

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults in intensive care who are on a breathing machine (mechanical ventilation) because of acute respiratory distress syndrome (ARDS).

Age

18 years or older

Sex

All sexes can join

Disease stage

ARDS as defined by the Berlin definition, in a person in intensive care on mechanical ventilation

Earlier treatment

Must be on mechanical ventilation in intensive care. At least one heart ultrasound (echocardiography) must have been done in one of the set time windows: first 24 hours of treatment, day 2 to 3, day 5 to 7, or within 48 hours of extubation.

Main reasons for not taking part

• Pregnancy
• Poor heart ultrasound image quality, so the size of the right and left ventricles cannot be measured reliably

The registry criteria, word for word

What the trial wants to find out

Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respiratory distress syndrome, the investigators will collect the data recorded on cardiac ultrasound, doses of cardiovascular drugs as well as variables reflecting hemodynamic status and cell oxygenation. Data will be collected during the course of ARDS and mechanical ventilation, as well as after weaning from artificial ventilation.

The group in the trial

• Patients with ARDS under mechanical ventilation

  * Age ≥18 years old * Hospitalization in intensive care * Presence of ARDS according to the current consensus definition