Studies blood vessel lining changes in people with coronary heart disease
Observes blood vessel function in adults with coronary heart disease before and after bypass surgery.
Plain-language title generated from the registry record
Registry title: Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
Key facts
- Where
- Osijek, CroatiaSee the site
Where in Croatia
- Osijek University HospitalOsijek, CroatiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Josip Juraj Strossmayer University of Osijek
- Trial code
- NCT07451873
- Record updated
- 9 March 2026
- Original description
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.Read full original descriptionShow less
The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective of the project is to increase the excellence and interdisciplinarity of scientific work at MEFOS by connecting researchers from different scientific fields, improving conditions and resources for scientific work, and increasing international cooperation, in line with strategic objective 1: raising scientific excellence. The results of the project could provide pathophysiological insight into the development and maintenance of endothelial dysfunction in CVD, as well as identify new biomarkers for CVD.
Inclusion: adult patients of both sexes over 18 years of age; Caucasian; undergoing elective coronary artery bypass grafting (CABG); provided written informed consent.
Exclusion: emergency surgery; sepsis or severe systemic inflammation before surgery; therapies that could affect oxidative stress (e.g., high doses of corticosteroids); severe renal or hepatic insufficiency; serious comorbidities (e.g., active cancer); immunosuppression.