Breathing Machine Pressure and Vein Congestion in Acute Respiratory Distress Syndrome
Observes how breathing machine pressure affects vein congestion in adults with acute respiratory distress syndrome.
Plain-language title generated from the registry record
Registry title: Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.
Key facts
- Where
- Angers, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07452952, who can take part
Where in France
- University hospital of AngersAngers, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Angers
- Trial code
- NCT07452952
- Record updated
- 5 March 2026
- Original description
The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.Read full original descriptionShow less
Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.
The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.
Inclusion: Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS as defined by the following criteria (1):; Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio <300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O; Pulmonary edema not fully explained by cardiac failure or fluid overload; Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules.
Exclusion: Renal or hepatic transplant recipient; Congenital heart disease; Portal vein thrombosis or Budd-Chiari syndrom; Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg; Persons subject to compulsory psychiatric care; Minor patient (<18 years old); ECMO (Extracorporeal Membrane Oxygenation); Hemodynamic instability (mean arterial pressure <60 mmHg); Respiratory instability (SpO₂ <90% under FiO₂ >90%); Severe organic tricuspid regurgitation; Pneumothorax; Liver cirrhosis Child-Pugh C; Pregnant, breastfeeding, or peripartum women; Persons deprived of liberty by judicial or administrative decision; Persons under legal protective measures.