NCT07454135Recruiting
Mechanisms of Atrial Pathoelectrophysiology in HCM
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual. Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them. The information from this study may help improve future treatments for people who have both HCM and AF.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 2 Mar 2026
- Start date
- 26 May 2026
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Guy's and St Thomas' NHS Foundation Trust
- NCT number
- NCT07454135
What you commit to
- Study type: Observational
- Planned participants: 40
- From 26 May 2026 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any disease limiting life expectancy to \<1 year
Lab values
- Contraindication to MRI including renal dysfunction (eGFR\<30ml/min)
Other
- Any clinical contra-indication to ablation
- Potential participant currently pregnant or breast feeding
- Unable to understand verbal or written explanations given in English
Who the study is looking for
- Paroxysmal or persistent atrial fibrillation
- Diagnosis of hypertrophic cardiomyopathy
- Patient planning to proceed to atrial fibrillation ablation following clinical consultation
- Age 18-80 years
- Able and willing to provide written informed consent
- Able and willing to comply with study follow up requirements
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.