Using MRI to look at lung airways in children with cystic fibrosis
Tests whether MRI can show airway size and shape in children with cystic fibrosis.
Plain-language title generated from the registry record
Registry title: MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .
Key facts
- Where
- Toronto, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 18 years old?
Source: NCT07454681, who can take part
Where in Canada
- Hospital for Sick ChildrenToronto, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Hospital for Sick Children
- Trial code
- NCT07454681
- Record updated
- 6 March 2026
- Original description
This study is being done to determine whether MRI can produce high quality lung and airway images in healthy and CF patients and if MRI can be used to evaluate size and shape of the airways with computer assistance. This study will also repeat MRI experiments two years after the initial MRI scan to see if changes to airway size and shape are seen over time. In a subset of participants, we will investigate whether MRI results are repeatable and reproducible in the short-term one week after the initial MRI visit. This study will help understand if MRI based measurements of airway size and shape can be used as a monitoring tool that does not use x-ray radiation in patients with CF.Read full original descriptionShow less
Development of Magnetic Resonance Imaging Airway Segmentation to Assess and Monitor Cystic Fibrosis Lung Disease
This study is being done to determine whether MRI can produce high quality lung and airway images in healthy and CF patients and if MRI can be used to evaluate size and shape of the airways with computer assistance. This study will also repeat MRI experiments two years after the initial MRI scan to see if changes to airway size and shape are seen over time. In a subset of participants, we will investigate whether MRI results are repeatable and reproducible in the short-term one week after the initial MRI visit. This study will help understand if MRI based measurements of airway size and shape can be used as a monitoring tool that does not use x-ray radiation in patients with CF.
Inclusion: Participants must be greater than or equal to 6 years of age and not greater than 18 years of age; Informed consent by patient or parent/guardian consent and participant assent when appropriate; Able to perform reproducible spirometry.
Exclusion: Usage of oral antibiotics within 3 weeks prior to study visit; Worsening cough and/or sputum production within the past 3 days prior to study visit; The use of new oral and/or inhaled antibiotics within 3 weeks prior to study visit; Received intravenous antibiotics within 2 weeks prior to study visit; Status of post lung or another organ transplant; Known pulmonary disease; Group 2 Inclusion Criteria; Participants must be greater than or equal to 6 years of age and not greater than 18 years of age; Medical instability that would preclude the ability to undergo the required investigations; FEV1 % predicted < 40%; Severe claustrophobia; Does not meet MRI screening criteria; Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen; Informed consent by patient or parent/guardian consent and participant assent when appropriate; Able to perform reproducible spirometry; Medical instability that would preclude the ability to undergo the required investigations; FEV1 % predicted < 40%; Severe claustrophobia; Does not meet MRI screening criteria; The use of supplementary oxygen.
Group 1.