How a mother's weight and diet relate to her breastmilk and baby's growth
Follows mothers and their babies, looking at diet, breastmilk and infant growth.
Plain-language title generated from the registry record
Registry title: Breastmilk and the Link to Overweight/Obesity and Maternal Diet in the Mother-breastmilk-child Triad
Key facts
- Where
- Vancouver, CanadaSee the site
Where in Canada
- Food, Nutrition and Health, Uviversity of British Columbia; Affiliated Investigator, Healthy Starts, BC Children's Hospital Research Institute & Women's Health Research InstituteVancouver, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Warsaw University of Life Sciences
- Trial code
- NCT07457515
- Record updated
- 9 March 2026
- Original description
The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity). The investigators plan 3 study visits (1, 3, and 6 months postpartum) with analysis the following parameters and outcomes:Read full original descriptionShow less
Analysis of the Transmission of Overweight/Obesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet
The prospective 5-month follow-up study will involve 150 mother-infant dyads grouped based on maternal baseline BMI category (normal weight, overweight, obesity). The investigators plan 3 study visits (1, 3, and 6 months postpartum) with analysis the following parameters and outcomes:
1. maternal anthropometry and body composition; 2. maternal dietary intake and dietary patterns (with results of biomarker-based validation); 3. maternal status of lipophilic antioxidants, selected vitamins, and fatty acids profile that may be related to adipose tissue metabolism, inflammation, and cardiometabolic status; 4. maternal metabolomics, adipokines, insulin, selected biomarkers of inflammation, altered glucose metabolism, and oxidation; 5. breastmilk composition assessed by systemic approach (macronutrients, fatty acids profile, lipophilic antioxidants, adipokines, hormones, immunological profile, and preliminary lipidomic analysis in part of the study group); 6. infant growth trajectory, body composition, urine metabolomics, and biomarkers of oxidative stress.
Additionally, maternal and infant stool, buccal swabs, and human milk samples will be banked for further microbiome analysis studies.
Inclusion: for mother:; at least 19 years,; plan of exclusively or predominantly breastfeeding for 6 months,; consent to a sampling of biological material and participate in all planned procedures (for both mother and infant),; willingness to finish the follow-up,; well-understanding of the Polish language (for non-Polish nationalities); for infants:; 1 month or less,; clinically healthy,; none or one formula feeding per day.
Exclusion: type 1 or 2 diabetes diagnosed before pregnancy,; uncontrolled thyroid disease,; congenital disease,; for mother:; breastfeeding more than 1 child or being a milk donor,; tobacco/alcohol use during pregnancy or currently,; inability to express a sufficient amount of milk; for infants:; birth from a multiple pregnancy,; preterm birth (<37 Hbd).