Deep Brain Stimulation in Two Brain Areas for Drug-Resistant Motor Epilepsy
Tests deep brain stimulation in two brain areas for adults with drug-resistant epilepsy.
Plain-language title generated from the registry record
Registry title: Combined CM and STN Stimulation for Motor Epilepsy
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07458217, who can take part
Where in China
- Xuanwu Hospital Capital Medical UniversBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Boston Scientific Corporation
- Trial code
- NCT07458217
- Record updated
- 30 October 2026
- Original description
This self-crossover, randomized controlled, pilot study aims to collect clinical data of bilateral stimulation of subthalamic nucleus (STN) combined with centromedian (CM) thalamus deep brain stimulation (DBS) for drug resistant epilepsy with motor symptom in adults.Read full original descriptionShow less
Combined CM and STN Stimulation for Motor Epilepsy
This self-crossover, randomized controlled, pilot study aims to collect clinical data of bilateral stimulation of subthalamic nucleus (STN) combined with centromedian (CM) thalamus deep brain stimulation (DBS) for drug resistant epilepsy with motor symptom in adults.
Inclusion: 1) 18-65 Years; 2) Drug Resistant Epilepsy; 3) Motor Epilepsy - defined as:; Epilepsy diagnosis meeting ILAE criteria; Motor Epilepsy defined as including one or more of:; Tonic, Clonic, or Tonic-Clonic activity; ii. Myoclonic Jerks; iii.Epileptic Spasms; iv.Focal Motor Seizures (identified primary lesion will be in motor functional area, such as primary motor cortex (BA4), pre-motor cortex (BA6), Central Posterior Gyrus (BA1-3), or other motor region); v.Motor activity not secondary to non-motor seizure. c.Clinical or Electrographic corroboration of at least one of: i.Video-EEG confirmation of motor seizure semiology; ii.Interictal or ictal EEG findings consistent with epileptic motor network involvement; iii.Consistent clinical description by trained cliniciants; 4) >3 Focal or Generalized seizures / month with an inter-seizure interval no great than 30 days; 5) Subject or caregiver is able to provide epileptic seizure record within 90 days prior to the surgery; 6) Voluntarily participate in the trial, sign the informed consent form, and be willing to comply with study requirements, including follow-ups.
Exclusion: 2) Previous diagnosis of psychogenic/non-epileptic seizures; 3) Brain lesion resection or ablation surgery performed less than 6 months; 1) Non Motor Epilepsy; 4) Implanted Vagus nerve stimulation (VNS) or responsive neurostimulation (RNS) devices recommended neither stimulation off the device at least 6 months nor remove the device; 5) Pregnant, breastfeeding, or having the intention to become pregnant during the study period (for females of childbearing potential).