Low-sodium salt substitute and blood potassium levels in adults with high blood pressure
Tests a low-sodium salt substitute for effects on blood potassium in adults with hypertension.
Plain-language title generated from the registry record
Registry title: The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension
Key facts
- Where
- Dhaka, BangladeshSee the site
Where in Bangladesh
- The National Heart Foundation of BangladeshDhaka, BangladeshTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT07460882
- Record updated
- 21 August 2026
- Original description
The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:Read full original descriptionShow less
The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension
The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:
Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population?
Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels?
Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.
Inclusion: Adults ≥18 years with clinically diagnosed hypertension treated with medication [on a stable dose at least for 2 months]; Have a phone for contact.
Exclusion: Other medical conditions determined by physicians (e.g., heart failure treated with medication; life expectancy less than 12 months); Those with baseline K ≥5.0 or K <3.0 mmol/L; Advanced kidney disease (eGFR <45 ml/min/1.73m2); Those on potassium sparing diuretics (e.g., spironolactone); Dine out for dinner more than 3 times a week.