Heat treatment for cervical pre-cancer in women with HPV infection
Tests a thermal ablation device for cervical pre-cancer in HPV-positive women.
Plain-language title generated from the registry record
Registry title: Point of Care - Triage and Treatment for Cervical Pre-cancer
Key facts
- Where
- San Salvador, El SalvadorSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 49 years old?
Source: NCT07461818, who can take part
Where in El Salvador
- Basic Health InternationalSan Salvador, El SalvadorTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Basic Health International, Inc.
- Trial code
- NCT07461818
- Record updated
- 28 August 2026
- Original description
This study evaluates a modified two-probe thermal ablation protocol using the IRIS™ device and retrospectively assesses an AI-based Automated Visual Evaluation (AVE) triage algorithm among HPV-positive women in El Salvador. The primary objective is to estimate 1-year cure rates of CIN2+ following treatment. A secondary objective is to evaluate the diagnostic performance of AVE compared with histopathology.Read full original descriptionShow less
POINT of CARE - Providing an Innovative New Triage and Treatment Strategy for Cervical Cancer Screening Efficiency
This study evaluates a modified two-probe thermal ablation protocol using the IRIS™ device and retrospectively assesses an AI-based Automated Visual Evaluation (AVE) triage algorithm among HPV-positive women in El Salvador. The primary objective is to estimate 1-year cure rates of CIN2+ following treatment. A secondary objective is to evaluate the diagnostic performance of AVE compared with histopathology.
Inclusion: Women aged 30-49 years; Non-pregnant (determined by urine pregnancy test); HPV-positive per Ministry of Health (MOH) records; Willing to undergo colposcopy and biopsies; Able and willing to provide informed consent.
Exclusion: History of LEEP or cervical ablation procedure in the past 5 years; History of total hysterectomy (verified by medical record or pelvic evaluation); History of cervical cancer; Plans to become pregnant during the study; Unable or unwilling to provide a permanent and reliable address; Unable or unwilling to provide informed consent.