Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Key facts
- Where
- Warsaw, PolandSee the 2 sites
Where in Poland
- Military Institute of Medicine - National Research InstituteWarsaw, PolandTaking people
- University of WarsawWarsaw, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Military Institute od Medicine National Research Institute
- Trial code
- NCT07462000
- Record updated
- 10 March 2026
- Original description
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.Read full original descriptionShow less
Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
Inclusion: Age ≥ 18 years; Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation); Ability to provide written informed consent; For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure; For control arm: cataract without glaucoma and without other significant ocular pathology.
Exclusion: Active or previous uveitis; Advanced visual impairment in the study eye (visual aquity worse than counting fingers); History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery; Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm); Age < 18 years; Pregnancy or breastfeeding; Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma); Inability to comply with study procedures or follow-up visits.