Nerve-guided keyhole surgery for liver cirrhosis with an enlarged spleen and portal hypertension
Tests nerve-guided keyhole spleen removal and vein disconnection in adults with cirrhosis.
Plain-language title generated from the registry record
Registry title: Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection
Key facts
- Where
- Yangzhou, ChinaSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with cirrhosis, an enlarged spleen with hypersplenism, and portal hypertension that has caused bleeding.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- Cirrhosis of any cause, with an enlarged spleen and secondary hypersplenism, and bleeding portal hypertension. Cirrhosis can be shown by clinical, imaging or tissue tests. Child-Pugh C cannot join.
- Biomarker or test result
- No blood clot in the portal vein system, shown by ultrasound and angio-CT.
Main reasons for not taking part
- Delayed gastric emptying or diarrhea
- Liver cancer or any other cancer
- Child-Pugh C cirrhosis
- Taking oral contraceptives, anticoagulant or anti-platelet drugs
- Pregnancy or HIV infection
Read by machine on 12 November 2026.
Where in China
- Clinical Medical College of Yangzhou UniversityYangzhou, ChinaContact: Guo-Qing Jiang, MSTaking people
- Clinical Medical College, Yangzhou UniversityYangzhou, ChinaContact: Guo-Qing Jiang, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Northern Jiangsu People's Hospital
- Trial code
- NCT07462091
- Record updated
- 1 April 2026
- Original description
This study aimed to evaluate the effectiveness and safety of vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection, and to assess its impact on postoperative digestive complications and quality of life.Read full original descriptionShow less
Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection
This study aimed to evaluate the effectiveness and safety of vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection, and to assess its impact on postoperative digestive complications and quality of life.
Inclusion: A clinical, radiological or histologic diagnosis of cirrhosis of any etiology; Splenomegaly with secondary hypersplenism; Bleeding portal hypertension; No evidence of portal vein system thrombosis by ultrasound evaluation and angio-CT; Informed consent to participate in the study.
Exclusion: Hepatocellular carcinoma or any other malignancy,; Hypercoagulable state other than the liver disease related; Recent peptic ulcer disease; History of Hemorrhagic stroke; Uncontrolled Hypertension; Human immunodeficiency virus (HIV) infection; DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs; Delayed gastric emptying; Diarrhea; Child - Pugh C; Pregnancy.