Advanced Brain Imaging-TKA (fMRI-TKA)
Key facts
- Where
- Ottawa, CanadaSee the site
Where in Canada
- The Ottawa HospitalOttawa, CanadaContact: Sanjula CostaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Ottawa Hospital Research Institute
- Trial code
- NCT07464080
- Record updated
- 11 March 2026
- Original description
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges.Read full original descriptionShow less
Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges.
This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Inclusion: Male and female patients aged 18 years or older; Primary TKA; Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis.
Exclusion: History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis; Cognitive impairment or dementia; Inability or refusal to sign informed consent form; Non-English or French speaking, and no licensed translator, family member or substitute decision maker available; Revision and/or Bilateral TKA; Chronic Opioid use.