Exercise for Movement and Thinking in People With Parkinson's Disease
Tests a combined movement and thinking exercise program in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Motor and Cognitive Exercise in Parkinson's Disease.
Key facts
- Where
- Copenhagen NV, DenmarkSee the site
Where in Denmark
- Department of Neurology, Bispebjerg and Frederiksberg HospitalCopenhagen NV, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Annemette Lokkegaard
- Trial code
- NCT07465107
- Record updated
- 11 March 2026
- Original description
The aim of this study is to examine the effects of a specialized multi-modal intervention in patients with moderate to advanced Parkinson's disease (PD). The hypothesis is that a specialized motor- and cognitive exercise program in addition to usual care can improve gait and balance better than usual care alone.Read full original descriptionShow less
Motor and Cognitive Exercise in Parkinson's Disease. A Feasibility Randomized Clinical Trial
The aim of this study is to examine the effects of a specialized multi-modal intervention in patients with moderate to advanced Parkinson's disease (PD). The hypothesis is that a specialized motor- and cognitive exercise program in addition to usual care can improve gait and balance better than usual care alone.
48 patients with PD and a symptom duration of 4 or more years will be randomized 1:1 to either a control arm or to an intervention arm. The control arm will have usual management of their PD. The intervention arm will receive exercises aimed at both motor and cognitive impairments of PD over the course of 12 weeks.
The study has been designed in partnership with the Copenhagen Trial Unit (CTU), Copenhagen Univeristy Hospital, to ensure both internal and external validity. To increase reproducibility, detailed protocols for all training modalities will be shared along with the study results.
This study is a feasibility study with the intention of a following international multi-center study to corroborate the results. Both feasibility outcomes for the intervention itself and clinical outcomes for the participants will be published.
Inclusion: Diagnosis of PD according to MDS-PD criteria; Aged ≥ 18 years; Informed consent; PD symptoms ≥ 4 years; Independent gait.
Exclusion: Diagnosis of PD Dementia according to the MDS-PD Dementia criteria.