Total Knee Arthroplasty in Varus Deformity
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- I.M. Sechenov First Moscow State Medical University
- Trial code
- NCT07465484
- Record updated
- 12 March 2026
- Original description
For the first time, a comparative analysis of the limb axis in patients with unilateral knee OA will be conducted compared to the contralateral uninjured side using Multisliced computed tomography (MSCT) and vertical CT (weight-bearing CT). This analysis will identify the pathological and physiological degrees of varus in patients with unilateral gonarthrosis. Indications for mechanical and kinematic limb axis alignment will be substantiated depending on the degree of varus deformity. Aim of the study: To improve the results of total knee arthroplasty in patients with varus deformity by optimizing the degree of varus correction. Objectives: To analyze physiological and pathological varus in patients with unilateral osteoarthritis under physiological loading. To develop an algorithm for applying various types of limb alignment.Read full original descriptionShow less
For the first time, a comparative analysis of the limb axis in patients with unilateral knee OA will be conducted compared to the contralateral uninjured side using Multisliced computed tomography (MSCT) and vertical CT (weight-bearing CT). This analysis will identify the pathological and physiological degrees of varus in patients with unilateral gonarthrosis. Indications for mechanical and kinematic limb axis alignment will be substantiated depending on the degree of varus deformity. Aim of the study: To improve the results of total knee arthroplasty in patients with varus deformity by optimizing the degree of varus correction. Objectives: To analyze physiological and pathological varus in patients with unilateral osteoarthritis under physiological loading. To develop an algorithm for applying various types of limb alignment.
Inclusion: Patients over 18 years of age with grade 3-4 knee osteoarthritis (according to Kellgren-Lawrence) and pain score of 5 or higher on a 10-point VAS scale; Varus deformity of the lower limb (HKA angle <177°, or varus >3°); Anesthesia risk according to the ASA scale of no more than III; BMI less than 35 kg/m2; Patient must be monitored throughout the entire study period (12 months); Patient must be mentally competent and compliant; Patient must provide written informed consent to participate in the study.
Exclusion: Presence of metal implants or foreign bodies in the lower extremities; Previous knee interventions, such as reconstruction of the knee ligament apparatus, or corrective osteotomies of the femur and tibia; Patient failure to comply with the recommendations of the treating physician or the prescribed regimen; Body mass index > 40 kg/m²; Instability of the collateral ligaments of the knee joint requiring the installation of ligamentous systems, presence of primary severe bone defects; Impaired weight-bearing ability of the contralateral limb; Patient refusal to participate in the study.