Two eye drop treatments after laser treatment for glaucoma
Compares Rocklatan and latanoprost drops after laser treatment in adults with glaucoma.
Plain-language title generated from the registry record
Registry title: Rocklatan vs Latanoprost Post-DSLT
Key facts
- Where
- Beaumont, United StatesSee the site
- Phase
- Phase 4
Where in United States
- Eye Centers of Southeast TexasBeaumont, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eye Centers of Southeast Texas
- Trial code
- NCT07465913
- Record updated
- 22 May 2026
- Original description
This is a randomized, double-masked, single-site, prospective, contralateral eye study designed to evaluate the outcomes of Direct Selective Laser Trabeculoplasty (DSLT) followed by the addition of combination netarsudil and latanoprost (Rocklatan) versus latanoprost monotherapy. The study will be conducted at one investigational site. The primary endpoint is the change in mean diurnal intraocular pressure (IOP) from baseline (post DSLT and post washout) at visit 3 between the two groups. Secondary endpoints include the change in mean IOP from baseline at each timepoint (8am, 12pm, 4pm) at visit 3 between groups, and the mean percentage decrease in IOP from baseline for each group. Assessments will be conducted at three key visits: Visit 1 (Screening Phase and DSLT Procedure on Day 0), Visit 2 (Baseline Visit post washout at Week 8), and Visit 3 (Follow-Up Visit 1 at Week 12). Each visit will include specific examinations and measurements such as visual field and OCT imaging, diurnal IOP measurements, and documentation of adverse events.Read full original descriptionShow less
Outcomes of Direct Selective Laser Trabeculoplasty With the Post-treatment Addition of Combination Netarsudil and Latanoprost vs Latanoprost Monotherapy
This is a randomized, double-masked, single-site, prospective, contralateral eye study designed to evaluate the outcomes of Direct Selective Laser Trabeculoplasty (DSLT) followed by the addition of combination netarsudil and latanoprost (Rocklatan) versus latanoprost monotherapy. The study will be conducted at one investigational site. The primary endpoint is the change in mean diurnal intraocular pressure (IOP) from baseline (post DSLT and post washout) at visit 3 between the two groups. Secondary endpoints include the change in mean IOP from baseline at each timepoint (8am, 12pm, 4pm) at visit 3 between groups, and the mean percentage decrease in IOP from baseline for each group. Assessments will be conducted at three key visits: Visit 1 (Screening Phase and DSLT Procedure on Day 0), Visit 2 (Baseline Visit post washout at Week 8), and Visit 3 (Follow-Up Visit 1 at Week 12). Each visit will include specific examinations and measurements such as visual field and OCT imaging, diurnal IOP measurements, and documentation of adverse events.
Inclusion: Adults (≥18 years) with a diagnosis of mild to moderate bilateral primary open-angle glaucoma (POAG) or open-angle glaucoma (OAG); On 3 topical glaucoma medications at screening, one of which must be a prostaglandin analog; Post-DSLT and post-washout, baseline intraocular pressure (IOP) 16-36 mmHg in both eyes; Best-corrected visual acuity (BCVA) ≥20/60 in both eyes; Ability and willingness to provide informed consent.
Exclusion: Inability or medical ineligibility for washout of ocular hypotensive medications; Prior selective laser trabeculoplasty (SLT) within 12 months of screening; Ocular hypertension only (no glaucomatous damage); History of glaucoma surgery (trabeculectomy, tube shunt, minimally invasive glaucoma surgery [MIGS] affecting outflow); Active ocular infection, uveitis, or severe dry eye; Known hypersensitivity to Rocklatan, latanoprost, or study medication components; Narrow or closed angles with gonioscopy (Shaffer grading ≤2); Corneal pathology interfering with IOP measurement; Advanced glaucoma (threat to fixation); Pregnancy or lactation.