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Geriatric-guided supportive care for frail older adults with diffuse large B-cell lymphoma

Compares geriatric-guided care with usual care in frail older adults with lymphoma.

Plain-language title generated from the registry record
Registry title: Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment

Key facts

Where
Ancona, Avellino, Aviano, Bari, Brescia, Cagliari, Florence, Milan, Monza, Padova, Palermo, Parma, Piacenza, Prato, Ravenna, Reggio Emilia, Roma, Siena, Teramo, Torino, Udine, and Verona, ItalySee the 24 sites

Where in Italy

  • Azienda Ospedaliero Universitaria delle Marche - S.O.D. Clinica EmatologicaAncona, ItalyNo longer taking part
  • A.O.R.N. S. Giuseppe Moscati - S.C. Ematologia e Trapianto emopoieticoAvellino, ItalyNo longer taking part
  • I.R.C.C.S. Centro di Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlatiAviano, ItalyNo longer taking part
  • I.R.C.C.S. Istituto Tumori Giovanni Paolo II - U.O.C. EmatologiaBari, ItalyNo longer taking part
  • A.S.S.T. Spedali Civili - S.C. EmatologiaBrescia, ItalyNo longer taking part
  • A.R.N.A.S. "Brotzu" P.O. Businco - S.C. Ematologia e TMOCagliari, ItalyNo longer taking part
  • A.O.U. Careggi - S.O.D. EmatologiaFlorence, ItalyNo longer taking part
  • A.S.S.T. Grande Ospedale Metropolitano Niguarda - S.C. EmatologiaMilan, ItalyNo longer taking part
  • I.R.C.C.S. Fondazione Cà Granda Ospedale Maggiore Policlinico - S.C. EmatologiaMilan, ItalyNo longer taking part
  • I.R.C.C.S. Fondazione San Gerardo dei Tintori - S.C. EmatologiaMonza, ItalyNo longer taking part
  • I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1Padova, ItalyNo longer taking part
  • A.O.U. Policlinico "Paolo Giaccone" - U.O.C. EmatologiaPalermo, ItalyNo longer taking part
  • Azienda Ospedaliero Universitaria di Parma - S.C. Ematologia e C.T.M.O.Parma, ItalyNo longer taking part
  • A.U.S.L. di Piacenza Osp. Guglielmo da Saliceto - U.O.C. Ematologia e Centro TrapiantiPiacenza, ItalyNo longer taking part
  • Azienda USL Toscana Centro - SOS OncoematologiaPrato, ItalyNo longer taking part
  • A.U.S.L. di Ravenna Osp. S. Maria delle Croci - U.O.C. EmatologiaRavenna, ItalyNo longer taking part
  • A.U.S.L. I.R.C.C.S. Arcispedale S. Maria Nuova - S.C. EmatologiaReggio Emilia, ItalyNo longer taking part
  • Fondazione Policlinico Campus Bio-Medico - U.O.C. Ematologia e trapianto di cellule staminaliRoma, ItalyNo longer taking part
  • A.O.U. Senese - U.O.C. EmatologiaSiena, ItalyNo longer taking part
  • A.S.L. Teramo Osp. "Giuseppe Mazzini" - U.O.S. EmatologiaTeramo, ItalyNo longer taking part
  • A.O.U. Città della Salute e della Scienza di Torino - S.C. EmatologiaTorino, ItalyNo longer taking part
  • A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia UTorino, ItalyNo longer taking part
  • A.S.U. Friuli Centrale - Clinica EmatologicaUdine, ItalyNo longer taking part
  • A.O.U.I. di Verona - U.O.C. EmatologiaVerona, ItalyNo longer taking part

Questions to ask the study team

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Trial details

Who runs it
Fondazione Italiana Linfomi - ETS
Trial code
NCT07476105
Record updated
15 April 2026
Original description
The aim of this multicenter, non-randomized, cluster controlled trial study is to evaluate the impact of a geriatric-guided approach with a pro-active rehabilitative/nutritional plan for elderly unfit/frail DLBCL patients eligible for receiving chemoimmunotherapy according to the sGA, versus a conventional approach with onco-hematological treatment alone.Read full original descriptionShow less

Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment. The Elderly Project 2.0: Non-randomized Cluster Controlled Trial

The aim of this multicenter, non-randomized, cluster controlled trial study is to evaluate the impact of a geriatric-guided approach with a pro-active rehabilitative/nutritional plan for elderly unfit/frail DLBCL patients eligible for receiving chemoimmunotherapy according to the sGA, versus a conventional approach with onco-hematological treatment alone.

A key innovation element of this project is to use a geriatric-guided approach to improve the global management of all frailty aspects (nutritional, functional, cognitive, social), chasing a better tolerance and completion rate of treatment, tailoring safety and efficacy of therapies in unfit/frail DLBCL patients.

This study may lead to a personalized approach for elderly DLBCL patients, taking into account a multidisciplinary and fully-integrated program, with the primary aim of improving the quality of life of patients and their families.

Inclusion: Diagnosis of DLBCL or Follicular Lymphoma (FL) grade IIIB; Age ≥ 70 years; UNFIT or FRAIL status according to sGA evaluated by the onco-hematologist at baseline; Patients eligible to a curative intent standard first line chemoimmunotherapy; Ability to understand and willingness to comply with study procedures; Signature of a written informed consent.

Exclusion: Patients not meeting at least one of the inclusion criteria listed above; Refuse to sign a written informed consent.

ClinicalTrials.gov NCT07476105