Tenecteplase for Minor but Disabling Stroke With a Blocked Large Artery
Tests tenecteplase against standard medicine in adults with minor, disabling stroke.
Plain-language title generated from the registry record
Registry title: Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
Key facts
- Where
- Anshan, Benxi, Chaoyang, Dalian, Dandong, Fushun, Fuxin, Fuzhou, Huludao, Jinzhou, Liaoyang, Panjin, Shenyang, Tieling, Wafangdian, and Yingkou, ChinaSee the 30 sites
- Phase
- Phase 3
Where in China
- Anshan Central HospitalAnshan, ChinaNo longer taking part
- Anshan Changda HospitalAnshan, ChinaNo longer taking part
- Benxi Central HospitalBenxi, ChinaNo longer taking part
- Chaoyang Central HospitalChaoyang, ChinaNo longer taking part
- Dalian Municipal Central Hospital Affiliated of Dalian University of TechnologyDalian, ChinaNo longer taking part
- Dandong Central HospitalDandong, ChinaNo longer taking part
- Dandong First HospitalDandong, ChinaNo longer taking part
- Fushun Central HospitalFushun, ChinaNo longer taking part
- Liaojian Group Fukuang General HospitalFushun, ChinaNo longer taking part
- Fuxin People's HospitalFuxin, ChinaNo longer taking part
- Fujian Medical University Union HospitalFuzhou, ChinaNo longer taking part
- Huludao Central HospitalHuludao, ChinaNo longer taking part
- The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou, ChinaNo longer taking part
- Liaoyang Central HospitalLiaoyang, ChinaNo longer taking part
- Panjin Central HospitalPanjin, ChinaNo longer taking part
- Central Hospital Affiliated to Shenyang Medical CollegeShenyang, ChinaNo longer taking part
- Liaoning Provincial People's HospitalShenyang, ChinaNo longer taking part
- Shenyang Fifth People's HospitalShenyang, ChinaNo longer taking part
- Shenyang First People's HospitalShenyang, ChinaNo longer taking part
- Shenyang Fourth People's HospitalShenyang, ChinaNo longer taking part
- Shenyang Tenth People's HospitalShenyang, ChinaNo longer taking part
- Sujiatun District Central HospitalShenyang, ChinaNo longer taking part
- The Fourth Affiliated Hospital of China Medical UniversityShenyang, ChinaNo longer taking part
- The Second Affiliated Hospital of Shenyang Medical CollegeShenyang, ChinaNo longer taking part
- Liaojian Group Tieling Coal General HospitalTieling, ChinaNo longer taking part
- Tieling Central HospitalTieling, ChinaNo longer taking part
- Tieling County Central HospitalTieling, ChinaNo longer taking part
- Wafangdian Central HospitalWafangdian, ChinaNo longer taking part
- Wafangdian Third People's HospitalWafangdian, ChinaNo longer taking part
- Yingkou Central HospitalYingkou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Hospital of China Medical University
- Trial code
- NCT07476898
- Record updated
- 17 March 2026
- Original description
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.Read full original descriptionShow less
A Multicenter, Randomized, Open-Label, Blinded-Endpoint Trial of Tenecteplase Versus Dual Antiplatelet Therapy in Mild Disabling Ischemic Stroke With Large Vessel Occlusion Beyond 4.5 Hours (TIME-MINOR Trial)
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
Inclusion: Male or female subjects (age ≥ 18 years); Diagnosis of acute ischemic stroke, with intracranial hemorrhage ruled out by CT or MRI; Time from stroke onset or last known well to randomization is 4.5 to 24 hours; NIHSS score 2-5 and meeting the definition of disabling deficit: complete hemianopia (NIHSS question 3 score ≥ 2); severe aphasia (NIHSS question 9 score ≥ 2); neglect (NIHSS question 11 score ≥ 1); any persistent limb weakness against gravity (NIHSS question 6 or 7 score ≥ 2); any functional deficit considered potentially disabling by the physician and patient, such as inability to perform basic activities of daily living (bathing, independent walking, toileting, personal hygiene, and eating) or return to work; LVO (internal carotid artery, middle cerebral artery M1/M2 segments) confirmed by CTA or MRA, including tandem lesions; Core infarct volume < 70 ml, ischemic penumbra volume ≥ 15 ml, and mismatch ratio ≥ 1.8, as shown by CTP or MRI+MRP; Written informed consent.
Exclusion: Major surgery within the last 1 month; Heparin or oral anticoagulant therapy within 48 hours; Thrombin or factor Xa inhibitors; Participation in any other investigational drug or device study within the last 3 months; Significant pre-stroke neurological deficit (pre-stroke mRS ≥ 2); History of stroke within the last 3 months; History of intracranial hemorrhage; Suspected subarachnoid hemorrhage; Severe illness with life expectancy < 3 months; Platelet count < 10⁵/mm³; Abnormal APTT; Blood glucose < 50 mg/dL (2.7 mmol/L); Intracranial tumor, vascular malformation, or aneurysm; Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg; Pregnancy; Patients deemed unsuitable for the registry study by the investigator.