Tests aerobic exercise training in people with Parkinson's disease
Tests a 12-week supervised aerobic exercise program against usual care in adults with Parkinson's.
Plain-language title generated from the registry record
Registry title: Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
Key facts
- Where
- São Paulo, BrazilSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Parkinson's disease at stages 1-3 who take stable medication and can walk on their own. It tests a 12-week supervised aerobic training program against usual care.
- Age
- 40 years and older
- Sex
- Men and women can join.
- Disease stage
- Clinical diagnosis of Parkinson's disease, Hoehn & Yahr stages 1-3.
- Earlier treatment
- Stable antiparkinsonian medication for at least 4 weeks.
- Biomarker or test result
- Montreal Cognitive Assessment (MoCA) score of 18 or higher.
Main reasons for not taking part
- A change in medication
- A contraindication to exercise
- Cannot walk independently (with or without an assistive device)
- No medical clearance for moderate-intensity exercise
Read by machine on 9 November 2026.
Where in Brazil
- Associação Brasil ParkinsonSão Paulo, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Raphael Mendes Ritti Dias
- Trial code
- NCT07478146
- Record updated
- 13 April 2026
- Original description
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.Read full original descriptionShow less
Effects of Aerobic Training on Cerebrovascular Function, Cognitive Performance and Gait Parameters in Patients With Parkinson's Disease: A Randomized Controlled Trial
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor symptoms, sleep, mood, gait biomechanics, quality of life, and body composition in patients with Parkinson's disease (Hoehn \& Yahr stages 1-3). Participants will be randomly allocated to aerobic training or usual care.
Inclusion: Clinical diagnosis of Parkinson's disease; Hoehn \& Yahr stages 1-3; Stable antiparkinsonian medication for at least 4 weeks; Montreal Cognitive Assessment (MoCA) score ≥ 18; Ability to walk independently (with or without assistive device); Medical clearance for participation in moderate-intensity exercise.
Exclusion: Change in medication; Contraindication to exercise.