Non-invasive deep brain stimulation for Parkinson's disease and its effect on brain networks
Tests non-invasive temporal interference stimulation of deep brain areas in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Key facts
- Where
- Nanjing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 65 years old?
Source: NCT07480317, who can take part
Where in China
- Nanjing Brain Hospital (Affiliated Brain Hospital of Nanjing Medical University)Nanjing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jiangsu Province Nanjing Brain Hospital
- Trial code
- NCT07480317
- Record updated
- 24 March 2026
- Original description
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients. Temporal interference stimulation (TIS) is a novel non-invasive technique that can target deep brain structures like the globus pallidus internus (GPi) by using high-frequency electric fields.Read full original descriptionShow less
Mechanism of Temporal Interference Stimulation on Brain Networks and Its Long-term Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients. Temporal interference stimulation (TIS) is a novel non-invasive technique that can target deep brain structures like the globus pallidus internus (GPi) by using high-frequency electric fields.
This study aims to evaluate the clinical value and underlying mechanisms of TIS in PD patients. The research is divided into two phases: Phase A investigates the immediate regulatory effects of 130 Hz and 40 Hz TIS on brain networks using concurrent fMRI-TIS. Phase B is a randomized, double-blind, sham-controlled trial to assess the long-term efficacy and safety of a 2-week TIS intervention on both motor and non-motor symptoms. The results will help clarify how TIS modulates deep brain networks and its potential as a non-invasive therapy for PD.
Inclusion: Diagnosed with Parkinson's Disease according to the Movement Disorder Society (MDS) clinical diagnostic criteria; Hoehn \& Yahr Stage I-III (mild to moderate severity); Aged 45 to 65 years; Right-handed. Stable medication regimen for at least 1 hour before Phase A fMRI sessions and agreement to maintain a stable dosage during the 2-week Phase B intervention (unless clinically necessary); Able to provide informed consent by the participant or a legal guardian.
Exclusion: MRI contraindications, such as implanted DBS electrodes, cardiac pacemakers, or other metal implants; Significant cognitive impairment (MoCA score < 24) or severe psychiatric symptoms; History of epilepsy or structural brain lesions, including severe cerebral atrophy or cerebrovascular disease; Severe head tremors that would interfere with MRI scanning quality.