Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease
Key facts
- Where
- Elâzığ, TürkiyeSee the site
Where in Türkiye
- Fethi Sekin City HospitalElâzığ, TürkiyeContact: SİNEM KESER, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Elazıg Fethi Sekin Sehir Hastanesi
- Trial code
- NCT07480720
- Record updated
- 18 March 2026
- Original description
This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease. Medical records of patients diagnosed with Graves disease and healthy control subjects evaluated at Elazığ Fethi Sekin City Hospital between August 2018 and January 2026 will be reviewed. Optical coherence tomography (OCT) measurements, including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, will be analyzed. Laboratory parameters such as complete blood count-derived inflammatory indices, C-reactive protein, thyroid function tests, and thyroid autoantibodies will also be recorded. The study will compare neuroretinal parameters between healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy, and will investigate potential associations between systemic inflammation, thyroid autoimmunity, and neuroretinal structural changes.Read full original descriptionShow less
Relationship Between Systemic Inflammation, Thyroid Autoimmunity, and Neuroretinal Structures in Graves Disease
This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease. Medical records of patients diagnosed with Graves disease and healthy control subjects evaluated at Elazığ Fethi Sekin City Hospital between August 2018 and January 2026 will be reviewed. Optical coherence tomography (OCT) measurements, including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, will be analyzed. Laboratory parameters such as complete blood count-derived inflammatory indices, C-reactive protein, thyroid function tests, and thyroid autoantibodies will also be recorded. The study will compare neuroretinal parameters between healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy, and will investigate potential associations between systemic inflammation, thyroid autoimmunity, and neuroretinal structural changes.
Inclusion: Age ≥ 18 years; Diagnosis of Graves' disease (for the patient group); No known thyroid disease in healthy control participants; Availability of optical coherence tomography (OCT) measurements and laboratory data; Time interval between OCT examination and blood sampling ≤ 10 days.
Exclusion: Presence of glaucoma, optic neuropathy, or retinal vascular diseases; Macular diseases, uveitis, or severe refractive error (high myopia >6 diopters); Diabetic retinopathy; History of previous intraocular surgery; History of active infection, malignancy, or systemic inflammatory disease; Poor-quality OCT measurements (segmentation errors or low signal strength).