NCT07484074CompletedPhase 1
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Two Different Formulations of Intravitreal OLN324 in Adult Participants With Either Neovascular (Wet) Age-related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)
Source: ClinicalTrials.gov · Last updated 19 Mar 2026
Brief summary (registry, in English)
A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 164 (actual)
- First submitted
- 9 Mar 2026
- Start date
- Feb 2025
- Primary completion date
- Oct 2025
- Lead sponsor
- Ollin Biosciences, Inc.
- Diseases
- Macular degeneration, Diabetic eye disease
- NCT number
- NCT07484074
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 164
- From Feb 2025 to the primary completion date, Oct 2025
- 30 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of cataract surgery and/or Yttrium-Aluminum Garnet (YAG) for removal of posterior capsular opacification (PCO) within 90 days
Other
- If pregnant or breastfeeding
Who the study is looking for
- Be willing and able to understand the study procedures and the risks involved and provide written informed consent before the first study-related activity
- DME patients must be ≥ 18 years of age, nAMD patients must be ≥ 50 years of age
- Diagnosis of either DME or nAMD. nAMD patients must be treatment naïve. DME patients can be either treatment naïve or treatment experienced
- DME patients must have best corrected visual acuity of 78 to 25 letters
- nAMD patients must have best corrected visual acuity of 80 to 25 letters
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (30)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Arecibo, Puerto Rico Coordinator of this site? Confirm its status | Arecibo | Puerto Rico | Unknown status |
| Abilene, TX Coordinator of this site? Confirm its status | Abilene | United States | Unknown status |
| Arlington, TX Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Austin, TX Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Bellaire, TX Coordinator of this site? Confirm its status | Bellaire | United States | Unknown status |
| Dallas, TX Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Fort Myers, FL Coordinator of this site? Confirm its status | Fort Myers | United States | Unknown status |
| Germantown, TN Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Glendale, CA Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Grand Rapids, MI Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Hagerstown, MD Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Katy, TX Coordinator of this site? Confirm its status | Katy | United States | Unknown status |
| Oak Forest, IL Coordinator of this site? Confirm its status | Oak Forest | United States | Unknown status |
| Pasadena, CA Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| Phoenix, AZ Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Plano, TX Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| Reno, NV Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Round Rock, TX Coordinator of this site? Confirm its status | Round Rock | United States | Unknown status |
| Sacramento, CA Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| San Antonio, TX Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| San Marcos, TX Coordinator of this site? Confirm its status | San Marcos | United States | Unknown status |
| Schertz, TX Coordinator of this site? Confirm its status | Schertz | United States | Unknown status |
| Springfield, OR Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Saint Petersburg, FL Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| The Woodlands, TX Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Tulsa, OK Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Wake Forest, NC Coordinator of this site? Confirm its status | Wake Forest | United States | Unknown status |
| Walnut Creek, CA Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Waterford, CT Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| Winter Haven, FL Coordinator of this site? Confirm its status | Winter Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.