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NCT07484074CompletedPhase 1

A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324

A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Two Different Formulations of Intravitreal OLN324 in Adult Participants With Either Neovascular (Wet) Age-related Macular Degeneration (nAMD) or Diabetic Macular Edema (DME)

Source: ClinicalTrials.gov · Last updated 19 Mar 2026

Brief summary (registry, in English)

A Phase 1b Study to Assess the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of Intravitreal OLN324

Status (registry)
Completed
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
164 (actual)
First submitted
9 Mar 2026
Start date
Feb 2025
Primary completion date
Oct 2025
Lead sponsor
Ollin Biosciences, Inc.
NCT number
NCT07484074

What you commit to

  • Study type: Interventional · Phase 1
  • Participants enrolled: 164
  • From Feb 2025 to the primary completion date, Oct 2025
  • 30 sites in 2 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • History of cataract surgery and/or Yttrium-Aluminum Garnet (YAG) for removal of posterior capsular opacification (PCO) within 90 days

Other

  • If pregnant or breastfeeding

Who the study is looking for

  • Be willing and able to understand the study procedures and the risks involved and provide written informed consent before the first study-related activity
  • DME patients must be ≥ 18 years of age, nAMD patients must be ≥ 50 years of age
  • Diagnosis of either DME or nAMD. nAMD patients must be treatment naïve. DME patients can be either treatment naïve or treatment experienced
  • DME patients must have best corrected visual acuity of 78 to 25 letters
  • nAMD patients must have best corrected visual acuity of 80 to 25 letters

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (30)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Arecibo, Puerto Rico
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AreciboPuerto RicoUnknown status
Abilene, TX
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AbileneUnited StatesUnknown status
Arlington, TX
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ArlingtonUnited StatesUnknown status
Austin, TX
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AustinUnited StatesUnknown status
Bellaire, TX
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BellaireUnited StatesUnknown status
Dallas, TX
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DallasUnited StatesUnknown status
Fort Myers, FL
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Fort MyersUnited StatesUnknown status
Germantown, TN
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GermantownUnited StatesUnknown status
Glendale, CA
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GlendaleUnited StatesUnknown status
Grand Rapids, MI
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Grand RapidsUnited StatesUnknown status
Hagerstown, MD
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HagerstownUnited StatesUnknown status
Katy, TX
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KatyUnited StatesUnknown status
Oak Forest, IL
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Oak ForestUnited StatesUnknown status
Pasadena, CA
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PasadenaUnited StatesUnknown status
Phoenix, AZ
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PhoenixUnited StatesUnknown status
Plano, TX
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PlanoUnited StatesUnknown status
Reno, NV
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RenoUnited StatesUnknown status
Round Rock, TX
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Round RockUnited StatesUnknown status
Sacramento, CA
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SacramentoUnited StatesUnknown status
San Antonio, TX
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San AntonioUnited StatesUnknown status
San Marcos, TX
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San MarcosUnited StatesUnknown status
Schertz, TX
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SchertzUnited StatesUnknown status
Springfield, OR
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SpringfieldUnited StatesUnknown status
Saint Petersburg, FL
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St. PetersburgUnited StatesUnknown status
The Woodlands, TX
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The WoodlandsUnited StatesUnknown status
Tulsa, OK
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TulsaUnited StatesUnknown status
Wake Forest, NC
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Wake ForestUnited StatesUnknown status
Walnut Creek, CA
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Walnut CreekUnited StatesUnknown status
Waterford, CT
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WaterfordUnited StatesUnknown status
Winter Haven, FL
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Winter HavenUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.