Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
Key facts
- Where
- Tübingen, GermanySee the site
- Phase
- Phase 1/2
Where in Germany
- University Hospital Tübingen, PICUTübingen, GermanyContact: Jan C Clausen, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Charite University, Berlin, Germany
- Trial code
- NCT07486167
- Record updated
- 15 October 2026
- Original description
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.Read full original descriptionShow less
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Function in Children With Congenital Heart Disease
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.
The primary hypothesis is that optimizing end-expiratory lung volume through a standardized PEEP titration maneuver improves cardiac performance and lung function.
Secondary objectives are to evaluate whether this strategy reduces duration of mechanical ventilation, improves hemodynamics and ventilation-perfusion matching, and decreases the need for vasopressor support.
Inclusion: Inclusion Criteria; congenital heart disease; surgery with cardiopulmonary bypass.
Exclusion: chronic lung disease; <36weeks of gestational age; single ventricle physiology; ECMO/VAD; Endotracheal tube leak > 15%; lack of informed consent from parents.