Plant-based diet and its effects in early-stage chronic lymphocytic leukemia
Tests a 4-week plant-based diet in adults with early-stage chronic lymphocytic leukemia.
Plain-language title generated from the registry record
Registry title: CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL
Key facts
- Where
- München, GermanySee the site
Where in Germany
- Klinikum der Technischen Universität München (Klinikum rechts der Isar)München, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Technical University of Munich
- Trial code
- NCT07487428
- Record updated
- 23 March 2026
- Original description
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are:Read full original descriptionShow less
An Interventional Study of Dietary Effects on Immune Function, Metabolism and Disease Activity in Early-Stage Chronic Lymphocytic Leukemia
The goal of this clinical trial is to investigate whether a short-term (4-week) whole-food, plant-based (WFPB) diet has an effect on metabolism, immune function, and disease activity in early-stage chronic lymphocytic leukemia (CLL). The main questions the study aims to answer are:
* Does a WFPB diet influence disease progression? * How do CLL cells and other immune cell types respond to a WFPB diet in terms of metabolism and signaling?
Researchers will examine whether a WFPB diet can affect absolute lymphocyte counts in participants' blood and what metabolic or functional changes occur within the CLL cells.
Participants will:
* Switch to a WFPB diet for 4 weeks following an introductory session with a certified dietary instructor. * Visit the clinic before starting the diet and again after 14 and 28 days for blood draws and to provide stool samples. * Keep a diary of all foods and drinks consumed during the week prior to and throughout the study period.
Inclusion: Confirmed CLL diagnosis; No previous treatments (watch and wait); Willingness to comply to a whole-food plant-based diet for 4 weeks; Willingness to participate in a total of 3 blood drawings.
Exclusion: Taking lipid-lowering medications (e.g. statins); Insulin-dependent diabetes; Emergency interventions; Patients that already follow a WFPB or vegan diet; Progression of CLL that implicates need for treatment; Body mass index (BMI) <20 And if in the opinion of the investigator there are any concerns regarding the ability of the patient to complete the study safely.